Results 101 to 110 of about 5,957,804 (303)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Spatio-temporal variations and multi-scale correlations of climate, water, land, and vegetation resources over the past four decades in the Heihe River Basin

Journal of Hydrology: Regional Studies
Study region: Heihe River Basin (HRB), Northwest China. Study focus: The study proposes an analytical scheme to identify trend, periodicity, and scale-correlation in climate, water, land, and vegetation resources over the past four decades using ...
Dandan Jiao, Shaomin Liu, Ziwei Xu, Lisheng Song, Yan Li, Rui Liu, Jiaxing Wei, Xinlei He, Dongxing Wu, Tongren Xu, Jingxin Guo   +10 more
doaj   +1 more source

The development of the ''in-line'' measurement of the surface texture

, 2021
Surface metrology "on-machine" and "in-process" is important for quality control in the production of precision surfaces. Classifications, requirements, and tasks of surface metrology "on the machine" and "in-progress" are processed. The most modern measuring systems "on-machine" and "inprocess" and sensor technology are presented. Debugging algorithms
Nedic, Bogdan, Petrovic Savic, Suzana, Ivković, Milan, Peko, Ivan, Djuric, Stefan   +4 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Development and Micro Manufacturing of Coronary Stents in Hungary [PDF]

, 2006
Revascularisation by endovascular implant (stent) has great importance in the treatment of coronary artery diseases. Stents are high-technology implants that are the creation of the knowledge of health sciences, physics, chemistry, material science and
Dobránszky, János, Major, László, Nyitrai, Zsolt, Szabó, Barnabás   +3 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Development of surface movement experimental platform and experimental study of buildings in mining area

Meitan xuebao
The mining influence of village buildings in the coal mining area is related to the local people’s livelihood and social stability. It is necessary to study the influence law and protection measures of surface movement and deformation on building damage ...
Yueguan YAN, Huayang DAI, Yuanhao ZHU
doaj   +1 more source

On some aspects of second order response surface methodology : a thesis presented in partial fulfilment of the requirements for the degree of M. Sc. in Mathematics at Massey University [PDF]

, 1972
A unified development of the theoretical basis of response surface methodology, particularly as it applies to second order response surfaces, is presented.
Thomas, Vernon John
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source