Results 91 to 100 of about 2,234,088 (265)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Same soybean policy, different responses of agricultural systems: Comparing effectiveness of cropping pattern adjusting in state farms and rural household farms of Heilongjiang, China

open access: yesGeography and Sustainability
State farms, although a minority in China’s agricultural sector, play a critical role in regions like Heilongjiang, leading national food production. However, how state farms (SFs) and rural household farms (RFs) respond to food policies, especially the ...
Xi Chen   +8 more
doaj   +1 more source

Development of a surface plasmon resonance biosensor for accurate and sensitive quantitation of small molecules in blood samples. [PDF]

open access: yesJ Pharm Anal, 2022
Qi M   +9 more
europepmc   +1 more source

Computer-Aided Design of Developable Surfaces: Designing with Developable Surfaces [PDF]

open access: yesJournal of Computers, 2018
Francisco Pérez-Arribas   +1 more
openaire   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Damage Development on the Surface of Nickel Coating in the Initial Period of Erosion. [PDF]

open access: yesMaterials (Basel), 2021
Zakrzewska DE   +5 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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