Results 41 to 50 of about 225,907 (267)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Dynamic Ranking of Refactoring Menu Items for Integrated Development Environment

open access: yesIEEE Access, 2018
Software refactoring is popular and thus most mainstream IDEs, e.g., Eclipse, provide a top level menu, especially for refactoring activities. The refactoring menu is designed to facilitate refactorings, and it has become one of the most commonly used ...
Thida Oo, Hui Liu, Bridget Nyirongo
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Ranking as Method of Evaluating Old-Industrial Regions in Russia

open access: yesВестник Российского экономического университета имени Г. В. Плеханова
Ranking is an acute method used in comparative estimation of regions in the system of state governance. The goal of ranking is to build typology and to carry out comparative analysis of old-industrial regions in order to assess the potential of their ...
N. Yu. Sorokina
doaj   +1 more source

Social Development Ranking of Districts of Pakistan [PDF]

open access: yesThe Pakistan Development Review, 1996
The paper has used eleven indicators relating to the education, health and water supply sectors to rank districts of Pakistan in terms of the level of social development. It also seeks to explain regional variation in the development of social infrastructure across districts.
A.F. Aisha Ghaus   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Indexing of planned investments in the EES [PDF]

open access: yesZbornik Radova: Elektrotehnički Institut "Nikola Tesla", 2018
The studies of planning development EES provide a set of solutions (investments) that need to be implemented in a certain period of time and for which it is necessary to allocate funds, in order to operate the technical system function within permissible
Stanković Miroslav   +3 more
doaj  

Requirements engineering issues causing software development outsourcing failure.

open access: yesPLoS ONE, 2020
Software development outsourcing is becoming more and more famous because of the advantages like cost abatement, process enhancement, and coping with the scarcity of needed resources.
Javed Iqbal   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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