Results 181 to 190 of about 3,151,387 (317)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bioengineering Outer-Membrane Vesicles for Vaccine Development: Strategies, Advances, and Perspectives. [PDF]

Vaccines (Basel)
Zahid A, Ismail H, Wilson JC, Grice ID.
europepmc   +1 more source

An Overview of Rift Valley Fever Vaccine Development Strategies. [PDF]

Vaccines (Basel), 2022
Kitandwe PK, McKay PF, Kaleebu P, Shattock RJ.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

WOMEN MEDIATORS IN MODERN PEACE PROCESSES: AN INSIGHT FROM SWITZERLAND [PDF]

Научно-аналитический вестник Института Европы РАН, 2022
Shevchuk Nina
doaj  

Evaluation of aerobic and anaerobic capacity in pubertal karate athletes: performance analysis and development strategies. [PDF]

BMC Sports Sci Med Rehabil
Korkmaz K, Aygören C, Düzova H.
europepmc   +1 more source

Exploiting the Potential of Magnetic Nanoparticles for Rapid Diagnosis Tests (RDTs): Nanoparticle-Antibody Conjugates and Color Development Strategies. [PDF]

Diagnostics (Basel), 2023
Ha Y.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Prioritizing oral bioavailability in drug development strategies. [PDF]

Future Med Chem
Xie L, Hong Y, Hu Y, Li H, Lou J, Zhou X.   +5 more
europepmc   +1 more source

Editorial: Decoding novel therapeutic targets, biomarkers, and drug development strategies against neurodegenerative disorders-A multi-omics approach. [PDF]

Front Comput Neurosci, 2023
Srinivasan E, Nagaraj S, Rajendran S, Rajasekaran R.   +3 more
europepmc   +1 more source