Results 251 to 260 of about 3,151,387 (317)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

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Sepsis Strategies in Development

Clinics in Chest Medicine, 2008
Severe sepsis, defined as inflammation and organ failure due to infection, continues to result in a mortality of approximately 30% despite advances in critical care. Current therapy includes timely administration of antibiotics, source control of infection, aggressive fluid resuscitation, support of failing organs, and use of activated protein C where ...
Steven P, LaRosa, Steven M, Opal
openaire   +2 more sources

Strategies for the development of metalloimmunotherapies

Nature Biomedical Engineering
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies.
Xiaoqi Sun, Xingwu Zhou, Xiaoyue Shi, Omar A. Abed, Xinran An, Yu Leo Lei, James J. Moon   +6 more
openaire   +2 more sources

Strategy For Development Administration

Journal of the Community Development Society, 1975
Neither development nor administration is static. In the past twenty years there have been major changes in both development and administration — changes in theory and in practice. Therefore, a consideration of strategy for development administration must begin with an examination of the evolution and prospects of the theory and practice of both ...
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Strategies for the Development of a Territory

2014 14th International Conference on Computational Science and Its Applications, 2014
Territorial marketing extends marketing from the company to the territorial contexts and much value at this regard is assumed by the Van den Berg's consideration [1], according to whom "a city should be managed as a business enterprise", where the orientation to the market constitutes an indispensable reference.
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Developing an is Education Strategy

Information Systems Management, 2001
Abstract Business firms are increasingly concerned with the education and learning of their employees.They recognize that their human capital is their most valuable resource, and they want to enhance their organization's effectiveness by ensuring that their people continue to develop intellectually.
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Development of rewriting strategies

1993
Algebraic program is considered as a system of rewriting rules jointly with rewriting strategy that may be represented in procedural form. The optimization of an algebraic program therefore is reduced to the development of optimal strategy and optimal implementation of it. This paper is devoted to the problem of finding optimal strategies for the given
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A Strategy for Development [PDF]

, 2002
This book is about a collection of speeches -all delivered since Nicholas Stern became Chief Economist of the World Bank in July 2000- they reflect insights that Mr. Stern has gained over more than three decades of study and work in development economics.
openaire   +1 more source