Results 131 to 140 of about 2,055,307 (265)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

[Development strategy of stomatology industry]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Yu G.
europepmc   +1 more source

Research and development strategy for biodegradable magnesium-based vascular stents: a review. [PDF]

Biomater Transl, 2021
Niu J, Huang H, Pei J, Jin Z, Guan S, Yuan G.   +5 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A novel EST-SSR fingerprint database development strategy for accurate identification of asparagus cultivars. [PDF]

BMC Plant Biol
Yi ZH, Wang Y, Song HX, Zhao J, Mao LP.
europepmc   +1 more source

Development Strategy of Intelligent Digital Library without Human Service in the Era of "Internet +".

Comput Intell Neurosci, 2022
Wang H, Ding J.
europepmc   +1 more source

Use of Real-World Evidence to Drive Drug Development Strategy and Inform Clinical Trial Design. [PDF]

Clin Pharmacol Ther, 2022
Dagenais S, Russo L, Madsen A, Webster J, Becnel L.   +4 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Review of advanced research on swine <i>Actinobacillus pleuropneumoniae</i> vaccine development strategy. [PDF]

Front Immunol
Tesfaye AB, Han R, Tao Z, You L, Zhu J, Gao P, Fu L, Chu Y.   +7 more
europepmc   +1 more source

The key issues and development strategy of Chinese Classical Formulas pharmaceutical preparations. [PDF]

Chin Med, 2021
Luo H, Chen H, Liu C, Zhang S, Vong CT, Tan D, Dai Y, Wang Y, Chen S.   +8 more
europepmc   +1 more source