Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Applications and development trend of biosensors in the detection and diagnosis of gastrointestinal tumors. [PDF]
Biomed Eng OnlineZhang C, Jin L, Wang F.
europepmc +1 more source
Predicting the development trend of the second wave of COVID-19 in five European countries. [PDF]
J Med Virol, 2021 Lei J, Li M, Wang X.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Development Trend and Key Technologies of Hydraulic End of High-Power Fracturing Pump
Shiyou jixieAs the development of unconventional oil and gas wells is increasingly difficult in China,the requirements are raised for the service life of hydraulic end of high-power fracturing pump in continuous fracturing operations with high power,ultrahigh ...
Yu Dawei, Tan Lijun, Shi Xijun
doaj
Feasibility analysis and development trend of nanomaterials for the treatment of pancreatic cancer. [PDF]
Discov NanoZhu J +6 more
europepmc +1 more source
Bibliometric review about eco-cites and urban sustainable development: trend topics. [PDF]
Environ Dev Sustain, 2022 Rodrigues M, Franco M.
europepmc +1 more source
Powerful Trend Function Tests That are Robust to Strong Serial Correlation with an Application to the Prebisch Singer Hypothesis [PDF]
In this paper we propose tests for hypothesis regarding the parameters of a the deterministic trend function of a univariate time series. The tests do not require knowledge of the form of serial correlation in the data and they are robust to strong ...
Helle Bunzel, Timothy Vogelsang
core
Preparation for Distributed Denial-of-Service (DDoS) Attacks: Cybersecurity Best Practices
This guide presents a series of best practices for preparing for distributed denial-of-service (DDoS) attacks that target cyberassets/business processes mainly to disable or disrupt their activity by creating an abnormal load on their resources ...
Inter-American Development Bank
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source