Results 121 to 130 of about 201,067 (302)

Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

eLife
A central goal of evolutionary developmental biology is to decipher the evolutionary pattern of gene regulatory networks (GRNs) that control embryonic development, and the mechanism underlying GRNs evolution.
Chenggang Shi, Shuang Chen, Huimin Liu, Rongrong Pan, Shiqi Li, Yanhui Wang, Xiaotong Wu, Jingjing Li, Xuewen Li, Chaofan Xing, Xian Liu, Yiquan Wang, Qingming Qu, Guang Li   +13 more
doaj   +1 more source

Switchable Nitroproteome States of Phytophthora infestans Biology and Pathobiology

Frontiers in Microbiology, 2019
The study demonstrates protein tyrosine nitration as a functional post-translational modification (PTM) in biology and pathobiology of the oomycete Phytophthora infestans (Mont.) de Bary, the most harmful pathogen of potato (Solanum tuberosum L.).
Karolina Izbiańska, Jolanta Floryszak-Wieczorek, Joanna Gajewska, Jarosław Gzyl, Tomasz Jelonek, Magdalena Arasimowicz-Jelonek   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Distinct mechanisms underlie pattern formation in the skin and skin appendages

, 2006
Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms that lead to the formation of patterns.
Chuong, CM, Maini, P. K., Widelitz, R. B., Maini, Philip, Paus, R, Plikus, Maksim, Paus, R., Plikus, M. V., Lin, C., Paus, Ralf, Widelitz, RB, Chuong, Cheng Ming, Lin, Chihmin, Baker, Ruth, Baker, RE, Baker, Ruth E., Lin, CM, Plikus, M., Chuong, C. M., Maini, Philip K., Plikus, M, Widelitz, Randall B., Widelitz, Randall B, Maini, PK, Lin, Chih Min   +24 more
core   +1 more source

Quantitative Insights into Developmental Signals and Phenotypes in C. elegans [PDF]

, 2008
Design of biomaterials and cellular scaffolds for tissue-engineering applications and regenerative medicine requires a precise understanding of the principles underlying multicellular patterning.
Giurumescu, Claudiu Adrian
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Patterning by cell-to-cell communication

, 2010
This thesis addresses the question of how patterning may arise through cell-to-cell communication. It combines quantitative data analysis with computational techniques to understand biological patterning processes.
Cohen, M.S.
core  

The role of hydrological transience in peatland pattern formation

, 2013
The sloping flanks of peatlands are commonly patterned with non-random, contour-parallel stripes of distinct microhabitats such as hummocks, lawns and hollows.
P. J. Morris, A. J. Baird, Belyea, LR, Morris, P. J., Belyea, L. R., Baird, AJ, L. R. Belyea, Baird, A. J., Morris, PJ   +8 more
core   +1 more source