Results 1 to 10 of about 7,143,981 (292)
F1000Research, 2016 Background: Acute high dose exposure to teratogenic chemicals alters the proper development of an embryo leading to infertility, impaired fecundity, and few viable offspring.
Alexis Killeen +1 more
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Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
Nature Communications, 2021 Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition
Constantin Cretu +9 more
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F1000Research, 2014 The "developmental hourglass'' describes a pattern of increasing morphological divergence towards earlier and later embryonic development, separated by a period of significant conservation across distant species (the "phylotypic stage'').
Saamer Akhshabi +3 more
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F1000Research, 2014 The "developmental hourglass'' describes a pattern of increasing morphological divergence towards earlier and later embryonic development, separated by a period of significant conservation across distant species (the "phylotypic stage'').
Saamer Akhshabi +3 more
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Molecular Mechanisms of Developmental and Tumor Angiogenesis
Brain Pathology, 1994 Angiogenesis, the sprouting of capillaries from preexisting vessels, is of fundamental importance during embryonic development and is the principal process by which the brain and certain other organs become vascularized. Angiogenesis occurs during embryonic development but is almost absent in adult tissues.
Plate, Karlheinz +2 more
openaire +3 more sources
Frontiers in Immunology, 2019 Efficient tuberculosis (TB) control depends on early TB prediction and prevention. Solution to these tasks requires knowledge of TB protection correlates (TB CoPs), i.e., laboratory markers that are mechanistically involved in the protection and which ...
Irina Lyadova +3 more
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F1000Research, 2016 Aims: To investigate the association between the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism rs 2236225 (c.1958G>A) and susceptibility to non-syndromic cleft of the lip and/or palate (NSCL/P).
Huaxiang Zhao +7 more
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Molecular and developmental mechanisms of anterior segment dysgenesis [PDF]
Eye, 2007 Anterior segment dysgenesis (ASD) is a failure of the normal development of the tissues of the anterior segment of the eye. It leads to anomalies in the structure of the mature anterior segment, associated with an increased risk of glaucoma and corneal opacity.
openaire +2 more sources
Recent Advances in Understanding Werner Syndrome [version 1; referees: 3 approved]
F1000Research, 2017 Aging, the universal phenomenon, affects human health and is the primary risk factor for major disease pathologies. Progeroid diseases, which mimic aging at an accelerated rate, have provided cues in understanding the hallmarks of aging. Mutations in DNA
Raghavendra A. Shamanna +3 more
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eLife, 2020 Primary Ovarian Insufficiency (POI) is a major cause of infertility, but its etiology remains poorly understood. Using whole-exome sequencing in a family with three cases of POI, we identified the candidate missense variant S167L in HSF2BP, an essential ...
Natalia Felipe-Medina +13 more
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