Results 21 to 30 of about 445,854 (255)

Recent Advances in Understanding Werner Syndrome [version 1; referees: 3 approved]

F1000Research, 2017
Aging, the universal phenomenon, affects human health and is the primary risk factor for major disease pathologies. Progeroid diseases, which mimic aging at an accelerated rate, have provided cues in understanding the hallmarks of aging. Mutations in DNA
Raghavendra A. Shamanna, Deborah L. Croteau, Jong-Hyuk Lee, Vilhelm A. Bohr   +3 more
doaj   +1 more source

Subdivisions of the adult zebrafish pallium based on molecular marker analysis [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2015
Background: The telencephalon shows a remarkable structural diversity among vertebrates. In particular, the everted telencephalon of ray-finned fishes has a markedly different morphology compared to the evaginated telencephalon of all other vertebrates ...
Julia Ganz, Volker Kroehne, Dorian Freudenreich, Anja Machate, Michaela Geffarth, Ingo Braasch, Jan Kaslin, Michael Brand   +7 more
doaj   +1 more source

A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

eLife, 2020
Primary Ovarian Insufficiency (POI) is a major cause of infertility, but its etiology remains poorly understood. Using whole-exome sequencing in a family with three cases of POI, we identified the candidate missense variant S167L in HSF2BP, an essential ...
Natalia Felipe-Medina, Sandrine Caburet, Fernando Sánchez-Sáez, Yazmine B Condezo, Dirk G de Rooij, Laura Gómez-H, Rodrigo Garcia-Valiente, Anne Laure Todeschini, Paloma Duque, Manuel Adolfo Sánchez-Martin, Stavit A Shalev, Elena Llano, Reiner A Veitia, Alberto M Pendás   +13 more
doaj   +1 more source

Novel targets of miR-30, a microRNA required for biliary development [v1; ref status: indexed, http://f1000r.es/1so]

F1000Research, 2013
MicroRNAs have been found to play a profound role in embryonic and post-natal development through their regulation of processes such as cell proliferation, differentiation, and morphogenesis.
Claire L. Le Guen, Joshua R. Friedman, Nicholas J. Hand   +2 more
doaj   +1 more source

Protocol for the visualization of pRps6-positive cells in larval zebrafish brains using whole-mount immunofluorescence and light-sheet microscopy

STAR Protocols
Summary: Due to their small size and transparency, larval zebrafish are a useful model for whole-brain imaging. Here, we present a protocol for the visualization of phosphorylated Rps6, a marker of mechanistic target of rapamycin complex 1 (mTORC1 ...
Olga Doszyn, Tomasz Dulski, Justyna Zmorzynska   +2 more
doaj   +1 more source

Subdivisions of the adult zebrafish pallium based on molecular marker analysis [v1; ref status: indexed, http://f1000r.es/4m2]

F1000Research, 2014
Background: The telencephalon shows a remarkable structural diversity among vertebrates. In particular, the everted telencephalon of ray-finned fishes has a markedly different morphology compared to the evaginated telencephalon of all other vertebrates ...
Julia Ganz, Volker Kroehne, Dorian Freudenreich, Anja Machate, Michaela Geffarth, Ingo Braasch, Jan Kaslin, Michael Brand   +7 more
doaj   +1 more source

Comparative transcriptomic analysis of the different developmental stages of ovary in red swamp crayfish Procambarus clarkii

BMC Genomics, 2021
Background The red swamp crayfish Procambarus clarkii is a freshwater species that possesses high adaptability, environmental tolerance, and fecundity. P. clarkii is artificially farmed on a large scale in China.
Yizhi Zhong, Wenbin Zhao, Zhangsheng Tang, Liming Huang, Xiangxing Zhu, Xiang Liang, Aifen Yan, Zhifa Lu, Yanling Yu, Dongsheng Tang, Dapeng Wang, Zhuanling Lu   +11 more
doaj   +1 more source

Protocol for microinjection of rapamycin into the zebrafish habenula

STAR Protocols
Summary: Mechanistic target of rapamycin complex 1 (mTorC1) activity plays a crucial role in brain development. Here, we present an approach for rapamycin microinjection into the habenula of larval zebrafish to achieve localized inhibition of the mTorC1 ...
Olga Doszyn, Tomasz Dulski, Justyna Zmorzynska   +2 more
doaj   +1 more source

Developmental gene regulatory networks in sea urchins and what we can learn from them [version 1; referees: 3 approved]

F1000Research, 2016
Sea urchin embryos begin zygotic transcription shortly after the egg is fertilized.  Throughout the cleavage stages a series of transcription factors are activated and, along with signaling through a number of pathways, at least 15 different cell types ...
Megan L. Martik, Deirdre C. Lyons, David R. McClay   +2 more
doaj   +1 more source

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

eLife, 2017
Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout
Naonobu Fujita, Wilson Huang, Tzu-han Lin, Jean-Francois Groulx, Steve Jean, Jen Nguyen, Yoshihiko Kuchitsu, Ikuko Koyama-Honda, Noboru Mizushima, Mitsunori Fukuda, Amy A Kiger   +10 more
doaj   +1 more source