Results 11 to 20 of about 445,854 (255)
Molecular mechanisms of developmentally programmed crinophagy in Drosophila [PDF]
Journal of Cell Biology, 2017 At the onset of metamorphosis, Drosophila salivary gland cells undergo a burst of glue granule secretion to attach the forming pupa to a solid surface. Here, we show that excess granules evading exocytosis are degraded via direct fusion with lysosomes, a secretory granule-specific autophagic process known as crinophagy.
Tamás Csizmadia +5 more
openaire +4 more sources
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
Nature Communications, 2021 Melanoma cells can switch between proliferative and invasive phenotypes. Here the authors show that the embryonic stem cell factor Sall4 is a negative regulator of melanoma phenotype switching where its loss leads to the acquisition of an invasive ...
Johanna Diener +16 more
doaj +1 more source
F1000Research, 2016 Background: Acute high dose exposure to teratogenic chemicals alters the proper development of an embryo leading to infertility, impaired fecundity, and few viable offspring.
Alexis Killeen +1 more
doaj +1 more source
Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
Nature Communications, 2021 Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition
Constantin Cretu +9 more
doaj +1 more source
F1000Research, 2014 The "developmental hourglass'' describes a pattern of increasing morphological divergence towards earlier and later embryonic development, separated by a period of significant conservation across distant species (the "phylotypic stage'').
Saamer Akhshabi +3 more
doaj +1 more source
Molecular Mechanisms of Developmental and Tumor Angiogenesis
Brain Pathology, 1994 Angiogenesis, the sprouting of capillaries from preexisting vessels, is of fundamental importance during embryonic development and is the principal process by which the brain and certain other organs become vascularized. Angiogenesis occurs during embryonic development but is almost absent in adult tissues.
Plate, Karlheinz +2 more
openaire +3 more sources
F1000Research, 2014 The "developmental hourglass'' describes a pattern of increasing morphological divergence towards earlier and later embryonic development, separated by a period of significant conservation across distant species (the "phylotypic stage'').
Saamer Akhshabi +3 more
doaj +1 more source
Frontiers in Immunology, 2019 Efficient tuberculosis (TB) control depends on early TB prediction and prevention. Solution to these tasks requires knowledge of TB protection correlates (TB CoPs), i.e., laboratory markers that are mechanistically involved in the protection and which ...
Irina Lyadova +3 more
doaj +1 more source
F1000Research, 2016 Aims: To investigate the association between the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism rs 2236225 (c.1958G>A) and susceptibility to non-syndromic cleft of the lip and/or palate (NSCL/P).
Huaxiang Zhao +7 more
doaj +1 more source
Molecular and developmental mechanisms of anterior segment dysgenesis [PDF]
Eye, 2007 Anterior segment dysgenesis (ASD) is a failure of the normal development of the tissues of the anterior segment of the eye. It leads to anomalies in the structure of the mature anterior segment, associated with an increased risk of glaucoma and corneal opacity.
openaire +2 more sources