Results 1 to 10 of about 194,471 (119)

The Immune System and Responses to Cancer: Coordinated Evolution [version 3; peer review: 2 approved]

open access: yesF1000Research, 2021
This review explores the incessant evolutionary interaction and co-development between immune system evolution and somatic evolution, to put it into context with the short, over 60-year, detailed human study of this extraordinary protective system.
Brendon J. Coventry, Maciej Henneberg
doaj   +1 more source

The Immune System and Responses to Cancer: Coordinated Evolution [version 2; peer review: 2 approved]

open access: yesF1000Research, 2020
This review explores the incessant evolutionary interaction and co-development between immune system evolution and somatic evolution, to put it into context with the short, over 60-year, detailed human study of this extraordinary protective system.
Brendon J. Coventry   +2 more
doaj   +1 more source

tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata [PDF]

open access: yesRoyal Society Open Science, 2018
Gap genes are involved in segment determination during early development of the vinegar fly Drosophila melanogaster and other dipteran insects (flies, midges and mosquitoes). They are expressed in overlapping domains along the antero-posterior (A–P) axis
Eva Jiménez-Guri   +2 more
doaj   +1 more source

Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure

open access: yeseLife, 2020
One of the fundamental gaps in our knowledge of how novel anatomical structures evolve is understanding the origins of the morphogenetic processes that form these features.
Sarah Jacquelyn Smith   +2 more
doaj   +1 more source

Task-specific odorant receptor expression in worker antennae indicates that sensory filters regulate division of labor in ants

open access: yesCommunications Biology, 2023
Division of labor (DOL) is a characteristic trait of insect societies, where tasks are generally performed by specialized individuals. Inside workers focus on brood or nest care, while others take risks by foraging outside.
Marcel A. Caminer   +5 more
doaj   +1 more source

Sculpting new structures

open access: yeseLife, 2020
The origins of the posterior lobe, a recently evolved structure in some species of Drosophila, have become clearer.
Jocelyn A McDonald, Yoshinori Tomoyasu
doaj   +1 more source

Origin of a folded repeat protein from an intrinsically disordered ancestor

open access: yeseLife, 2016
Repetitive proteins are thought to have arisen through the amplification of subdomain-sized peptides. Many of these originated in a non-repetitive context as cofactors of RNA-based replication and catalysis, and required the RNA to assume their active ...
Hongbo Zhu   +9 more
doaj   +1 more source

Structural diversity of oligomeric β-propellers with different numbers of identical blades

open access: yeseLife, 2019
β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain.
Evgenia Afanasieva   +7 more
doaj   +1 more source

α/β coiled coils

open access: yeseLife, 2016
Coiled coils are the best-understood protein fold, as their backbone structure can uniquely be described by parametric equations. This level of understanding has allowed their manipulation in unprecedented detail.
Marcus D Hartmann   +6 more
doaj   +1 more source

Single-cell RNA sequencing of the Strongylocentrotus purpuratus larva reveals the blueprint of major cell types and nervous system of a non-chordate deuterostome

open access: yeseLife, 2021
Identifying the molecular fingerprint of organismal cell types is key for understanding their function and evolution. Here, we use single-cell RNA sequencing (scRNA-seq) to survey the cell types of the sea urchin early pluteus larva, representing an ...
Periklis Paganos   +4 more
doaj   +1 more source

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