Results 41 to 50 of about 823,004 (286)

Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies [PDF]

, 2009
In this article we will discuss the integration of developmental patterning mechanisms with waves of competency that control the ability of a homogeneous field of cells to react to pattern forming cues and generate spatially heterogeneous patterns.
Baker, Ruth E., Maini, P. K., Schnell, S.   +2 more
core   +3 more sources

Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

Open Biology, 2022
Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term ‘embryonic’ might appear to be a misnomer to several people because these pathways are functional during the early stages of embryonic development and adulthood, albeit to a certain degree ...
Niraj Kumar Jha, Wei-Chih Chen, Sanjay Kumar, Rajni Dubey, Lung-Wen Tsai, Rohan Kar, Saurabh Kumar Jha, Piyush Kumar Gupta, Ankur Sharma, Rohit Gundamaraju, Kumud Pant, Shalini Mani, Sandeep Kumar Singh, Ricardo B. Maccioni, Tirtharaj Datta, Sachin Kumar Singh, Gaurav Gupta, Parteek Prasher, Kamal Dua, Abhijit Dey, Charu Sharma, Yasir Hayat Mughal, Janne Ruokolainen, Kavindra Kumar Kesari, Shreesh Ojha   +24 more
openaire   +6 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Quantitative tandem affinity purification, an effective tool to investigate protein complex composition in plant hormone signaling : strigolactones in the spotlight [PDF]

, 2018
Phytohormones tightly regulate plant growth by integrating changing environmental and developmental cues. Although the key players have been identified in many plant hormonal pathways, the molecular mechanisms and mode of action of perception and ...
Boyer, François-Didier, Braem, Lukas, De Jaeger, Geert, De Keyser, Annick, Gevaert, Kris, Goormachtig, Sofie, Persiau, Geert, Struk, Sylwia Magdalena, Walton, Alan   +8 more
core   +2 more sources

A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports the Drosophila model of CDKL5 deficiency disorder

Frontiers in Cell and Developmental Biology
The human CDK-like (CDKL) family of serine‒threonine kinases has five members (CDKL1-5), with a conserved N-terminal kinase domain and variable C-termini.
María del Carmen Martín-Carrascosa, María del Carmen Martín-Carrascosa, María del Carmen Martín-Carrascosa, Christian Palacios-Martínez, Máximo Ibo Galindo, Máximo Ibo Galindo, Máximo Ibo Galindo   +6 more
doaj   +1 more source

Arterial dysgenesis and limb defects : Clinical and experimental examples [PDF]

, 2017
Acknowledgements This article is dedicated to Dr David S. Packard Jr. With thanks to Dr John DeSesso, Dr Lewis B. Holmes, Dr Mark Levinsohn, Dr David S.
Hootnick, David R., Vargesson, Neil
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Hyperactive mTORC1 disrupts habenula function and light preference in zebrafish model of Tuberous sclerosis complex

iScience
Summary: Mechanistic target of rapamycin complex 1 (mTORC1) is an integration hub for extracellular and intracellular signals necessary for brain development.
Olga Doszyn, Magdalena Kedra, Justyna Zmorzynska   +2 more
doaj   +1 more source

Dynamics of cell polarity in tissue morphogenesis: a comparative view from Drosophila and Ciona [version 1; referees: 2 approved]

F1000Research, 2016
Tissues in developing embryos exhibit complex and dynamic rearrangements that shape forming organs, limbs, and body axes. Directed migration, mediolateral intercalation, lumen formation, and other rearrangements influence the topology and topography of ...
Michael T. Veeman, Jocelyn A. McDonald
doaj   +1 more source

Molecular Mechanisms of Developmental Timing in C. elegans and Drosophila [PDF]

Developmental Cell, 2001
Characterization of the heterochronic genes has provided a strong foundation for understanding the molecular mechanisms of developmental timing in C. elegans. In apparent contrast, studies of developmental timing in Drosophila have demonstrated a central role for gene cascades triggered by the steroid hormone ecdysone.
openaire   +2 more sources