Results 1 to 10 of about 423,637 (219)

Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity

Frontiers in Cell and Developmental Biology, 2023
Maternal diabetes and obesity in pregnancy are well-known risk factors for structural birth defects, including neural tube defects and congenital heart defects.
Man Zhang, J. Michael Salbaum, Sydney Jones, David Burk, Claudia Kappen   +4 more
doaj   +1 more source

Nutrient Transporter Gene Expression in the Early Conceptus—Implications From Two Mouse Models of Diabetic Pregnancy

Frontiers in Cell and Developmental Biology, 2022
Maternal diabetes in early pregnancy increases the risk for birth defects in the offspring, particularly heart, and neural tube defects. While elevated glucose levels are characteristic for diabetic pregnancies, these are also accompanied by ...
Claudia Kappen, Claudia Kruger, Sydney Jones, J. Michael Salbaum   +3 more
doaj   +1 more source

Broad spectrum of CRISPR-induced edits in an embryonic lethal gene

Scientific Reports, 2021
Mendelian genetics poses practical limitations on the number of mutant genes that can be investigated simultaneously for their roles in embryonic development in the mouse.
Kayla T. B. Fuselier, J. Michael Salbaum, Claudia Kappen   +2 more
doaj   +1 more source

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Cell Reports, 2021
Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of ...
Seraina Blümli, Nicola Wiechens, Meng-Ying Wu, Vijender Singh, Marek Gierlinski, Gabriele Schweikert, Nick Gilbert, Catherine Naughton, Ramasubramanian Sundaramoorthy, Joby Varghese, Robert Gourlay, Renata Soares, David Clark, Tom Owen-Hughes   +13 more
doaj   +1 more source

Differential responses to maternal diabetes in embryo and visceral yolk sac

Frontiers in Cell and Developmental Biology, 2023
Introduction: Maternal diabetes during pregnancy is well known to be associated with a higher risk for structural birth defects in the offspring. Recent searches for underlying mechanisms have largely focused on aberrant processes in the embryo itself ...
J. Michael Salbaum, Kirsten P. Stone, Claudia Kruger, Claudia Kappen   +3 more
doaj   +1 more source

TempShift Reveals the Sequential Development of Human Neocortex and Skewed Developmental Timing of Down Syndrome Brains

Brain Sciences, 2023
Development is a complex process involving precise regulation. Developmental regulation may vary in tissues and individuals, and is often altered in disorders.
Yuqiu Zhou, Li Tao, Ying Zhu
doaj   +1 more source

chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development

Caspian Journal of Neurological Sciences, 2022
Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in ...
Farzam Ajamian, Mohammad Mehdi Sohani, Farhad Mashayekhi, Afsaneh Shokri, Seyedeh Rezvaneh Moadabpour   +4 more
doaj   +1 more source

BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes

eLife, 2020
Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore ...
Laura Bel Borja, Flavie Soubigou, Samuel J P Taylor, Conchita Fraguas Bringas, Jacqueline Budrewicz, Pablo Lara-Gonzalez, Christopher G Sorensen Turpin, Joshua N Bembenek, Dhanya K Cheerambathur, Federico Pelisch   +9 more
doaj   +1 more source

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Nature Communications, 2021
Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural ...
Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M. M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W. E. Santen, Marco Trizzino   +14 more
doaj   +1 more source

Developmental regulation of GABAergic gene expression in forebrain cholinergic neurons

Frontiers in Neural Circuits, 2023
Acetylcholine and GABA are often co-released, including from VIP-expressing neurons of the cortex, cortically-projecting neurons of the globus pallidus externus and basal forebrain, and hippocampal-projecting neurons of the medial septum.
Adam J. Granger, Karen Mao, Jessica L. Saulnier, Morgan E. Hines, Bernardo L. Sabatini   +4 more
doaj   +1 more source