Results 11 to 20 of about 741,473 (304)

TempShift Reveals the Sequential Development of Human Neocortex and Skewed Developmental Timing of Down Syndrome Brains

open access: yesBrain Sciences, 2023
Development is a complex process involving precise regulation. Developmental regulation may vary in tissues and individuals, and is often altered in disorders.
Yuqiu Zhou, Li Tao, Ying Zhu
doaj   +1 more source

chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development

open access: yesCaspian Journal of Neurological Sciences, 2022
Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in ...
Farzam Ajamian   +4 more
doaj   +1 more source

BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes

open access: yeseLife, 2020
Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore ...
Laura Bel Borja   +9 more
doaj   +1 more source

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

open access: yesNature Communications, 2021
Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural ...
Luca Pagliaroli   +14 more
doaj   +1 more source

The regulation of Hox gene expression during animal development [PDF]

open access: yes, 2013
Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns ...
Alonso, Claudio R, Mallo, Moisés
core   +1 more source

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse

open access: yesNeurobiology of Disease, 2022
Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded by the SCNxA family and four are predominately expressed in the brain: SCN1A, SCN2A, SCN3A, and ...
Jacqueline Heighway   +8 more
doaj   +1 more source

Developmental regulation and expression of the zebrafish connexin43 gene [PDF]

open access: yesDevelopmental Dynamics, 2005
AbstractWe cloned and sequenced the zebrafish (Danio rerio) connexin43 (Cx43α1) gene. The predicted protein sequence shows a high degree of sequence conservation. Transcript analyses revealed multiple transcription start sites and a potential alternative transcript encoding a N‐terminally truncated Cx43α1 protein.
Bishwanath, Chatterjee   +12 more
openaire   +2 more sources

Recent advances in signal integration mechanisms in the unfolded protein response [version 1; peer review: 2 approved]

open access: yesF1000Research, 2019
Since its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the ...
G. Elif Karagöz   +2 more
doaj   +1 more source

Phylogeny, expression patterns and regulation of DNA Methyltransferases in early development of the flatfish, Solea senegalensis [PDF]

open access: yes, 2017
Background: The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fish.
Armesto, Paula   +5 more
core   +2 more sources

Transcription of satellite DNAs in insects [PDF]

open access: yes, 2011
Chromatin condensation is an important regulatory mechanism of gene silencing as well as gene activation for the hundreds of functional protein genes harbored in heterochromatic regions of different insect species.
D. Ugarkovic   +3 more
core   +1 more source

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