Results 11 to 20 of about 437,526 (312)

Epigenetic regulation during fetal femur development: DNA methylation matters. [PDF]

PLoS ONE, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
María C de Andrés, Emmajayne Kingham, Kei Imagawa, Antonio Gonzalez, Helmtrud I Roach, David I Wilson, Richard O C Oreffo   +6 more
doaj   +2 more sources

TempShift Reveals the Sequential Development of Human Neocortex and Skewed Developmental Timing of Down Syndrome Brains

Brain Sciences, 2023
Development is a complex process involving precise regulation. Developmental regulation may vary in tissues and individuals, and is often altered in disorders.
Yuqiu Zhou, Li Tao, Ying Zhu
doaj   +1 more source

chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development

Caspian Journal of Neurological Sciences, 2022
Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in ...
Farzam Ajamian, Mohammad Mehdi Sohani, Farhad Mashayekhi, Afsaneh Shokri, Seyedeh Rezvaneh Moadabpour   +4 more
doaj   +1 more source

BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes

eLife, 2020
Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore ...
Laura Bel Borja, Flavie Soubigou, Samuel J P Taylor, Conchita Fraguas Bringas, Jacqueline Budrewicz, Pablo Lara-Gonzalez, Christopher G Sorensen Turpin, Joshua N Bembenek, Dhanya K Cheerambathur, Federico Pelisch   +9 more
doaj   +1 more source

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Nature Communications, 2021
Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural ...
Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M. M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W. E. Santen, Marco Trizzino   +14 more
doaj   +1 more source

A chicken homeo box gene with developmentally regulated expression [PDF]

FEBS Letters, 1989
Several homeo box sequences were isolated from a chicken (Gallus domesticus) genomic library. One phage, λGG7, was chosen for further study and the single homeo box sequence it contains was characterized. The sequence of the homeo box revealed it to be a distant member of the Antp class of homeo boxes.
Fainsod, Abraham, Gruenbaum, Yosef
openaire   +2 more sources

Role of Topoisomerase IIβ in the Expression of Developmentally Regulated Genes [PDF]

Molecular and Cellular Biology, 2006
Mice lacking topoisomerase IIbeta (TopIIbeta) are known to exhibit a perinatal death phenotype. In the current study, transcription profiles of the brains of wild-type and top2beta knockout mouse embryos were generated. Surprisingly, only a small number (1 to 4%) of genes were affected in top2beta knockout embryos. However, the expression of nearly 30%
Yi Lisa, Lyu, Chao-Po, Lin, Anna M, Azarova, Li, Cai, James C, Wang, Leroy F, Liu   +5 more
openaire   +2 more sources

Gene expression in a drosophila model of mitochondrial disease [PDF]

, 2010
Background A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, was previously shown to cause a phenotype of respiratory chain deficiency, developmental delay, and neurological abnormalities similar to ...
Esko Kemppainen, Jacobs, H.T., Daniel J M Fernández-Ayala, Shanjun Chen, Fernandez-Ayala, Daniel JM, Kemppainen, E., Kevin M C O'Dell, O'Dell, Kevin MC, Jacobs, Howard T, Chen, S., Chen, Shanjun, Kemppainen, Esko, O'Dell, K.M.C., Kevin M. C. O'Dell, Howard T. Jacobs, Fernández-Ayala, D.J.M., Howard T Jacobs, Daniel J. M. Fernández-Ayala   +17 more
core   +1 more source

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse

Neurobiology of Disease, 2022
Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded by the SCNxA family and four are predominately expressed in the brain: SCN1A, SCN2A, SCN3A, and ...
Jacqueline Heighway, Alicia Sedo, Anjali Garg, Lauren Eldershaw, Victoria Perreau, Géza Berecki, Christopher A. Reid, Steven Petrou, Snezana Maljevic   +8 more
doaj   +1 more source

A specific group of genes respond to cold dehydration stress in cut Alstroemeria flowers whereas ambient dehydration stress accelerates developmental senescence expression patterns [PDF]

, 2010
Petal development and senescence entails a normally irreversible process. It starts with petal expansion and pigment production, and ends with nutrient remobilization and ultimately cell death.
Rogers, H., Thornber, Sarah, Thornber, Sarah Elizabeth, Irene Bramke, Bramke, I., Tony Stead, Rogers, Hilary Joan, Vicky Buchanan-Wollaston, Thornber, S., Stead, T., Elizabeth Harrison, Rogers, Hilary, Breeze, E., Wagstaff, Carol, Bramke, Irene, Brian Thomas, Carol Wagstaff, Emily Breeze, Breeze, Emily, Harrison, Elizabeth, Buchanan-Wollaston, V., Thomas, Bryan, Sarah Thornber, Stead, Tony, Buchanan-Wollaston, Vicky, Hilary Rogers, Thomas, B., Thomas, Brian, Harrison, E.   +28 more
core   +1 more source