Results 11 to 20 of about 423,637 (219)
Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster
Bioscience Reports, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
Daniel Bandarra +4 more
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Neurobiology of Disease, 2022 Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded by the SCNxA family and four are predominately expressed in the brain: SCN1A, SCN2A, SCN3A, and ...
Jacqueline Heighway +8 more
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F1000Research, 2019 Since its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the ...
G. Elif Karagöz +2 more
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Dynamic association of NUP98 with the human genome. [PDF]
PLoS Genetics, 2013 Faithful execution of developmental gene expression programs occurs at multiple levels and involves many different components such as transcription factors, histone-modification enzymes, and mRNA processing proteins.
Yun Liang +4 more
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Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach
Cell Reports, 2019 Summary: R-loops are three-stranded DNA:RNA hybrids that are implicated in many nuclear processes. While R-loops may have physiological roles, the formation of stable, aberrant R-loops has been observed in neurological disorders and cancers.
Qingqing Yan +3 more
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Conservation of peripheral nervous system formation mechanisms in divergent ascidian embryos
eLife, 2020 Ascidians with very similar embryos but highly divergent genomes are thought to have undergone extensive developmental system drift. We compared, in four species (Ciona and Phallusia for Phlebobranchia, Molgula and Halocynthia for Stolidobranchia), gene ...
Joshua F Coulcher +8 more
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Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development
Scientific Reports, 2022 The transcriptome is subject to rapid and massive changes during the transition between developmental stages. These changes require tight control to avoid the undesired reactivation of gene expression that is only important for previous developmental ...
Guillaume Bordet +2 more
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Nature Communications, 2022 Our understanding of the extent of involvement of DNA methylation in genome-wide gene regulation and plant developmental control is incomplete. Here, the authors knock out all five known DNA methyltransferases and show the developmental and gene ...
Li He +8 more
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mRNA Cap Methylation in Pluripotency and Differentiation
Cell Reports, 2016 The mRNA cap recruits factors essential for transcript processing and translation initiation. We report that regulated mRNA cap methylation is a feature of embryonic stem cell (ESC) differentiation. Expression of the mRNA cap methyltransferase activating
Laura Grasso +9 more
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Transcriptome sequencing and developmental regulation of gene expression in Anopheles aquasalis. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND:Anopheles aquasalis is a major malaria vector in coastal areas of South and Central America where it breeds preferentially in brackish water.
André L Costa-da-Silva +12 more
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