Results 41 to 50 of about 437,526 (312)
Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila
Journal of Developmental Biology, 2018 Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and ...
Giuliana D. Clemente +6 more
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PLoS Neglected Tropical Diseases, 2022 BackgroundAedes albopictus originated in the tropical forests of Southeast Asia and can currently be found on all continents. As one of the main arboviral vectors, the control of Ae.
Wenjuan Liu +5 more
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MicroRNAs Instruct and Maintain Cell Type Diversity in the Nervous System
Frontiers in Molecular Neuroscience, 2021 Characterizing the diverse cell types that make up the nervous system is essential for understanding how the nervous system is structured and ultimately how it functions.
Norjin Zolboot +4 more
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Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei:evidence for genome-wide conservation of life-cycle stage-specific regulatory elements [PDF]
, 2006 Trypanosomes represent an excellent model for the post-transcriptional regulation of gene expression because their genome is organized into polycistronic transcription units.
Katelyn Fenn +10 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
Regulation of gene expression by micrornas : targeting specificity, kinetics and function [PDF]
, 2011 Summary: Understanding gene regulation is a central question of molecular biology. For decades, gene expression was thought to be controlled by a complex network of proteins called transcription factors.
Hausser, Jean Albert René
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The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Scientific ReportsObesity is characterized by dysregulated adipogenesis that leads to increased number and/or size of adipocytes. Understanding the molecular mechanisms governing adipogenesis is therefore key to designing therapeutic interventions against obesity.
Salwa Mohd Mostafa +4 more
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Nuclear Actin Is Required for Transcription during Drosophila Oogenesis
iScience, 2018 Summary: Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function.
Maria Sokolova +9 more
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Conserved translatome remodeling in nematode species executing a shared developmental transition. [PDF]
PLoS Genetics, 2013 Nematodes of the genus Caenorhabditis enter a developmental diapause state after hatching in the absence of food. To better understand the relative contributions of distinct regulatory modalities to gene expression changes associated with this ...
Michael Stadler, Andrew Fire
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