Results 51 to 60 of about 741,473 (304)

A compartmentalized regulator of developmental gene expression in Bacillus subtilis [PDF]

Journal of Bacteriology, 1996
We have identified a new Bacillus subtilis gene, spoVT, whose gene product is homologous to the transcriptional regulator AbrB and serves as a regulator of E sigmaG-controlled gene expression. SpoVT acts both positively and negatively in controlling sigmaG-dependent gene expression, providing an additional level of refinement to forespore gene ...
I, Bagyan, J, Hobot, S, Cutting
openaire   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation

Scientific Reports
Obesity is characterized by dysregulated adipogenesis that leads to increased number and/or size of adipocytes. Understanding the molecular mechanisms governing adipogenesis is therefore key to designing therapeutic interventions against obesity.
Salwa Mohd Mostafa, Luyang Wang, Bin Tian, Joel Graber, Claire Moore   +4 more
doaj   +1 more source

Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation. [PDF]

PLoS Genetics, 2018
Cis-regulation plays an essential role in the control of gene expression, and is particularly complex and poorly understood for developmental genes, which are subject to multiple levels of modulation.
Patrick Torbey, Elodie Thierion, Samuel Collombet, Anne de Cian, Carole Desmarquet-Trin-Dinh, Mathilde Dura, Jean-Paul Concordet, Patrick Charnay, Pascale Gilardi-Hebenstreit   +8 more
doaj   +1 more source

Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity [PDF]

, 2015
Much of development and disease concerns the generation of gene expression differences between related cells sharing similar niches. However, most analyses of gene expression only assess population and time-averaged levels of steady-state transcription ...
Cannon, D, Chubb, JR, Corrigan, AM, McDonel, P, Miermont, A   +4 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Nuclear Actin Is Required for Transcription during Drosophila Oogenesis

iScience, 2018
Summary: Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function.
Maria Sokolova, Henna M. Moore, Bina Prajapati, Joseph Dopie, Leena Meriläinen, Mikko Honkanen, Rita Cerejeira Matos, Minna Poukkula, Ville Hietakangas, Maria K. Vartiainen   +9 more
doaj   +1 more source

Conserved translatome remodeling in nematode species executing a shared developmental transition. [PDF]

PLoS Genetics, 2013
Nematodes of the genus Caenorhabditis enter a developmental diapause state after hatching in the absence of food. To better understand the relative contributions of distinct regulatory modalities to gene expression changes associated with this ...
Michael Stadler, Andrew Fire
doaj   +1 more source

High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation [PDF]

, 2011
Leaf senescence is an essential developmental process that impacts dramatically on crop yields and involves altered regulation of thousands of genes and many metabolic and signaling pathways, resulting in major changes in the leaf.
Beynon, Jim, Breeze, Emily, Buchanan-Wollaston, Vicky, Denby, Katherine J., Harrison, Elizabeth, Hickman, Richard J., Hill, Claire, Hughes, Linda Karen, Jackson, Stephen D., Jenkins, Dafyd J., Jenner, Carol E., Kiddle, Steven J., Kim, Youn-sung, Legaie, Roxane, McHattie, Stuart, Mead, A., Moore, Jonathan D., Morris, Karl, Ott, Sascha, Penfold, Christopher A., Rand, D. A., Tabrett, Alex, Thomas, Brian, Wild, David L., Zhang, Cunjin   +24 more
core   +2 more sources

Zebrafish rest regulates developmental gene expression but not neurogenesis [PDF]

Development, 2012
The transcriptional repressor Rest (Nrsf) recruits chromatin-modifying complexes to RE1 ‘silencer elements’, which are associated with hundreds of neural genes. However, the requirement for Rest-mediated transcriptional regulation of embryonic development and cell fate is poorly understood. Conflicting views of the role of Rest in controlling cell fate
Fatma O, Kok, Andrew, Taibi, Sarah J, Wanner, Xiayang, Xie, Cara E, Moravec, Crystal E, Love, Victoria E, Prince, Jeff S, Mumm, Howard I, Sirotkin   +8 more
openaire   +2 more sources