Results 61 to 70 of about 7,339,069 (294)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Functional genomic analysis of developmental control gene action in the embryonic nervous system of "Drosophila" [PDF]
, 2003 In the past two decades, developmental genetic analysis of the molecular control elements involved in early embryonic brain patterning has uncovered the existence of structurally and functionally homologous genes that have comparable, and indeed ...
Montalta-He, Haiqiong
core +1 more source
Distinguishing epigenetic marks of developmental and imprinting regulation
Epigenetics & Chromatin, 2010 Background The field of epigenetics is developing rapidly, however we are only beginning to comprehend the complexity of its influence on gene regulation.
McEwen Kirsten R, Ferguson-Smith Anne C
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Spatiotemporal expression patterns of cytosolic AtHSP90-2 in Arabidopsis seedlings
Plant Signaling & Behavior, 2023 Heat shock protein AtHSP90–2 is one of the three constitutive cytosolic HSP90s of Arabidopsis thaliana, which are highly homologous and show mild expression activation in response to stressful impacts.
Liudmyla Kozeko, Elizabeth Kordyum
doaj +1 more source
Zebrafish rest regulates developmental gene expression but not neurogenesis [PDF]
Development, 2012 The transcriptional repressor Rest (Nrsf) recruits chromatin-modifying complexes to RE1 ‘silencer elements’, which are associated with hundreds of neural genes. However, the requirement for Rest-mediated transcriptional regulation of embryonic development and cell fate is poorly understood. Conflicting views of the role of Rest in controlling cell fate
Fatma O, Kok +8 more
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Differential Gene Expression and Protein Abundance Evince Ontogenetic Bias toward Castes in a Primitively Eusocial Wasp [PDF]
, 2010 Polistes paper wasps are models for understanding conditions that may have characterized the origin of worker and queen castes and, therefore, the origin of paper wasp sociality.
Hunt, James H +17 more
core +2 more sources
NELF potentiates gene transcription in the Drosophila embryo. [PDF]
PLoS ONE, 2010 A hallmark of genes that are subject to developmental regulation of transcriptional elongation is association of the negative elongation factor NELF with the paused RNA polymerase complex.
Xiaoling Wang +3 more
doaj +1 more source