Does cohesin regulate developmental gene expression in Drosophila ? [PDF]
Proceedings of the National Academy of Sciences, 2008 Cohesin is a conserved protein complex with a well documented role in providing stable but reversible connections between sister chromatids during both mitosis and meiosis. Cohesin consists of two long coiled-coil proteins (SMC1 and SMC3) and two non-SMC subunits (SCC1/Rad21 and SCC3/SA) that combine to form a ring-like structure.
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription
Nature CommunicationsFluctuations in the initiation rate of transcription, the first step in gene expression, ensue from the stochastic behavior of the molecular process that controls transcription.
Robert Shelansky +6 more
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Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation. [PDF]
, 1991 The integrin alpha 6 beta 1 is a prominent laminin receptor used by many cell types. In the present work, we isolate clones and determine the primary sequence of the chick integrin alpha 6 subunit.
de Curtis, I +3 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Enhancer mediated regulation of developmental gene expression
The FASEB Journal, 2012 Cell‐fate transitions involve the integration of genomic information encoded by regulatory elements, such as enhancers, with cellular and signaling environments. Identification of genomic sequences that control human embryonic development represents a formidable challenge, as they are embedded within a vast non‐coding genomic space.
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Distinguishing epigenetic marks of developmental and imprinting regulation
Epigenetics & Chromatin, 2010 Background The field of epigenetics is developing rapidly, however we are only beginning to comprehend the complexity of its influence on gene regulation.
McEwen Kirsten R, Ferguson-Smith Anne C
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Development of functional ectopic compound eyes in scarabaeid beetles by knockdown of orthodenticle [PDF]
, 2017 Complex traits like limbs, brains, or eyes form through coordinated integration of diverse cell fates across developmental space and time, yet understanding how complexity and integration emerge from uniform, undifferentiated precursor tissues remains ...
Busey, Hannah A. +3 more
core +1 more source
Zebrafish churchill regulates developmental gene expression and cell migration [PDF]
Developmental Dynamics, 2013 Background: Regulation of developmental signaling pathways is essential for embryogenesis. The small putative zinc finger protein, Churchill (ChCh) has been implicated in modulation of both TGF‐β and FGF signaling. Results: We used zinc finger nuclease (ZFN) mediated gene targeting to disrupt the zebrafish chch locus and generate the first chch ...
Andrew, Taibi +6 more
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