Results 91 to 100 of about 7,339,069 (294)

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Schmid, Wolfgang, Schütz, Günther, Nitsch, Doris   +3 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei [PDF]

, 2009
Background: Trypanosomes undergo extensive developmental changes during their complex life cycle. Crucial among these is the transition between slender and stumpy bloodstream forms and, thereafter, the differentiation from stumpy to tsetse-midgut ...
Ross Alan, Sarah Kabani, Katelyn Fenn, Keith Matthews, Matthews Keith, Kabani, Sarah, Matthews, Keith; id_orcid, Terry K Smith, Ghazal, Peter, Fenn Katelyn, Al Ivens, Smith Terry K, Smith, Terry K., Ghazal Peter, Kabani Sarah, Smith, Terry K, Ross, Alan, Fenn, Katelyn, Peter Ghazal, Ivens, Al, Matthews, Keith, Ivens Al, Alan Ross   +22 more
core   +1 more source

Developmental phase transitions in Norway spruce [PDF]

, 2013
Plant development proceeds through distinct phases that are controlled by complex networks of regulatory genetic circuits and fine-tuned by environmental and endogenous cues.
Uddenberg, Daniel
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Developmental Regulation of Small-Conductance Ca²⁺-Activated K⁺ Channel Expression and Function in Rat Purkinje Neurons [PDF]

, 2002
Calcium transients play an important role in the early and later phases of differentiation and maturation of single neurons and neuronal networks. Small-conductance calcium-activated potassium channels of the SK type modulate membrane excitability and ...
Stocker, M, Pedarzani P., Stocker, M., Pedarzani, P, Cingolani, L., Cingolani L, Gymnopoulos, M., Boccaccio, A, Cingolani, L. A., Gymnopoulos M, Boccaccio A, Gymnopoulos, Marco, Boccaccio, A., Cingolani, LA, Gymnopoulos, M, Pedarzani, P., Stocker M   +16 more
core   +1 more source

Differential gene expression mediates physiological responses to perceived predation risk in a developmentally plastic vertebrate, the northern leopard frog (Lithobates pipiens)

Frontiers in Ecology and Evolution
Prey can respond to predation risk through developmental plasticity, generating anti-predator phenotypes. These inducible defenses arise from changes to the stress axis, and neuroendocrine-triggered gene regulation is a likely mechanism influencing such ...
Tucker W. Cambridge, Michael E. Donaldson, Leslie R. Kerr, David Lesbarrères, Jessica N. Longhi, Jeffrey R. Row, Barry J. Saville, Dennis L. Murray   +7 more
doaj   +1 more source

Inferring gene expression dynamics via functional regression analysis

BMC Bioinformatics, 2008
Background Temporal gene expression profiles characterize the time-dynamics of expression of specific genes and are increasingly collected in current gene expression experiments.
Leng Xiaoyan, Chiou Jeng-Min, Müller Hans-Georg   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Developmental regulation of diacylglycerol acyltransferase family gene expression in tung tree tissues.

PLoS ONE, 2013
Diacylglycerol acyltransferases (DGAT) catalyze the final and rate-limiting step of triacylglycerol (TAG) biosynthesis in eukaryotic organisms. DGAT genes have been identified in numerous organisms. Multiple isoforms of DGAT are present in eukaryotes. We
Heping Cao, Jay M Shockey, K Thomas Klasson, Dorselyn C Chapital, Catherine B Mason, Brian E Scheffler   +5 more
doaj   +1 more source