Results 161 to 170 of about 181,587 (216)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Biological Roles of Class II Hydrophobins at the Cell Wall of Filamentous Ascomycetes. [PDF]

J Basic Microbiol
Hansberg W, Páez O.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Understanding the Specification Mechanism of the Megaspore Mother Cell in <i>Arabidopsis</i>. [PDF]

Biology (Basel)
Yu L, Ma S, Xi X, He P, Cai H.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervation. [PDF]

Proc Natl Acad Sci U S A
Adams AMJ, Wu KLK, Li Z, Li P, Pan H, Huang Z, Migliarini S, Dear R, Sun B, Chan ZC, Liang J, Li H, Vértes PE, Pasqualetti M, Isakova A, Ren J.   +15 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Ikram Blilou. [PDF]

New Phytol
europepmc   +1 more source

Integrated Transcriptome and WGCNA Analyses Reveal Candidate Regulatory Networks Associated with Shell Hardening in <i>Macadamia integrifolia</i>. [PDF]

Plants (Basel)
Long Q, Li Y, Geng J, Gong L, Wu C, Ma J, Li T, Zi N, Tu X, Tao L.   +9 more
europepmc   +1 more source