Results 111 to 120 of about 608,296 (310)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia

iScience, 2023
Summary: Pancreatic development requires spatially and temporally controlled expression of growth factors derived from mesenchyme. Here, we report that in mice the secreted factor Fgf9 is expressed principally by mesenchyme and then mesothelium during ...
Sophie Patzek, Zhe Liu, Sean de la O, Sean Chang, Lauren E. Byrnes, Xiuqin Zhang, David M. Ornitz, Julie B. Sneddon   +7 more
doaj  

A Representation of Changes of Images and its Application for Developmental Biolology [PDF]

arXiv, 2003
In this paper, we consider a series of events observed at spaced time intervals and present a method of representation of the series. To explain an idea, by dealing with a set of gene expression data, which could be obtained from developmental biology, the procedures are sketched with comments in some details.
arxiv  

The Machine Conception of the Organism in Development and Evolution: A Critical Analysis [PDF]

, 2014
This article critically examines one of the most prevalent metaphors in modern biology, namely the machine conception of the organism (MCO). Although the fundamental differences between organisms and machines make the MCO an inadequate metaphor for ...
Nicholson, Daniel J.
core  

Partial differential equations for self-organization in cellular and developmental biology [PDF]

, 2008
Understanding the mechanisms governing and regulating the emergence of structure and heterogeneity within cellular systems, such as the developing embryo, represents a multiscale challenge typifying current integrative biology research, namely ...
Acheson D J, Alberts B, Andrews S S, Baker R E, Bender C M, Briggs G E, Britton N F, Chang C, Cohen D S, Crampin E J, Cruywagen G C, E A Gaffney, Erban R Chapman S J Maini P K, Fenchel T, Fife P C, Gomez T M, Grindrod P, Jiang T X, Juhlin S P, Keener J P, Lander A D, Lengeler J W, Lin C M Jiang Y J Baker R E Maini P K Widelitz R B Chuong C M, Meinhardt H, Murray J D, Murray J D, Myerscough M R, Namba R, Newman S A, Ockendon J R, Oster G F, P K Maini, R E Baker, Schnell S, Weinan E, Wolpert L   +35 more
core   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

An e-Infrastructure for Collaborative Research in Human Embryo Development [PDF]

arXiv, 2009
Within the context of the EU Design Study Developmental Gene Expression Map, we identify a set of challenges when facilitating collaborative research on early human embryo development. These challenges bring forth requirements, for which we have identified solutions and technology.
arxiv  

An optical coherence microscope for 3-dimensional imaging in developmental biology [PDF]

, 2000
An optical coherence microscope (OCM) has been designed and constructed to acquire 3-dimensional images of highly scattering biological tissue. Volume-rendering software is used to enhance 3-D visualization of the data sets. Lateral resolution of the OCM
Fernandez, Andrew D., Fraser, Scott E., Haskell, Richard C., Hoeling, Barbara M., Huang, Erik, Myers, Whittier R., Petersen, Daniel C., Ungersma, Sharon E., Wang, Ruye, Williams, Mary E.   +9 more
core   +2 more sources

Quantitative approaches in developmental biology

Nature Reviews Genetics, 2009
The tissues of a developing embryo are simultaneously patterned, moved and differentiated according to an exchange of information between their constituent cells. We argue that these complex self-organizing phenomena can only be fully understood with quantitative mathematical frameworks that allow specific hypotheses to be formulated and tested.
Oates, A. C., Gorfinkiel, N., González-Gaitán, M., Heisenberg, C.-P.   +3 more
openaire   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source