Results 151 to 160 of about 608,296 (310)

Developmental Biology and Pathology. (Current Topics in Pathology.) [PDF]

, 1978
K. M. Laurence
openalex   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus

iScience
Summary: Mitochondria are key organelles to provide ATP for synaptic transmission. This study aims to unravel the structural adaptation of mitochondria to an increase in presynaptic energy demand and upon the functional impairment of the auditory system.
Anika Hintze, Felix Lange, Anna M. Steyer, Jannis Anstatt, Wiebke Möbius, Stefan Jakobs, Carolin Wichmann   +6 more
doaj  

NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation

iScience, 2023
Summary: In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the development ...
Sabrina Giampaolo, Cristina M. Chiarolla, Konrad Knöpper, Martin Vaeth, Matthias Klein, Azeem Muhammad, Tobias Bopp, Friederike Berberich-Siebelt, Amiya K. Patra, Edgar Serfling, Stefan Klein-Hessling   +10 more
doaj  

Resolving the paradox of evolvability with learning theory: How evolution learns to improve evolvability on rugged fitness landscapes [PDF]

arXiv, 2016
It has been hypothesized that one of the main reasons evolution has been able to produce such impressive adaptations is because it has improved its own ability to evolve -- "the evolution of evolvability". Rupert Riedl, for example, an early pioneer of evolutionary developmental biology, suggested that the evolution of complex adaptations is ...
arxiv  

Developmental Biology Explorations in Developmental Biology Chandler Fulton Atilla O. Klein [PDF]

, 1977
Ralph T. Hinegardner
openalex   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Drosophila SPARC collagen IV chaperone-like activity essential for development is unique to the fat body

iScience
Summary: Drosophila fat body-derived SPARC acts as a chaperone for collagen IV (Col(IV)), enabling their diffusion and incorporation into distal tissue basement membranes (BMs). Disruption of SPARC or Col(IV) production by the fat body is lethal, despite
Samuel Delage, Arya Zadhoosh, William You, Theodore Joseph Brown, Maurice Joseph Ringuette   +4 more
doaj  

Time-resolved phosphoproteome and proteome analysis reveals kinase signaling on master transcription factors during myogenesis

iScience, 2022
Summary: Myogenesis is governed by signaling networks that are tightly regulated in a time-dependent manner. Although different protein kinases have been identified, knowledge of the global signaling networks and their downstream substrates during ...
Di Xiao, Marissa Caldow, Hani Jieun Kim, Ronnie Blazev, Rene Koopman, Deborah Manandi, Benjamin L. Parker, Pengyi Yang   +7 more
doaj  

On Programs and Genomes [PDF]

arXiv, 2011
We outline the global control architecture of genomes. A theory of genomic control information is presented. The concept of a developmental control network called a cene (for control gene) is introduced. We distinguish parts-genes from control genes or cenes.
arxiv