Results 141 to 150 of about 580,764 (305)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Society for Developmental Biology
The Society for Developmental Biology (SDB) works "to further the study of development in all organisms and at all levels, to represent and promote communication among students of development, and to promote the field of developmental biology."
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Identification of novel factors that promote spindle positioning in the C. elegans embryo
, 2012 LIN-5, GPR-1/2, and the Ga proteins GOA-1 and GPA-16, have previously been identified as key regulators of spindle positioning. In this thesis we identified other components that contribute to the different spindle and nuclear positioning events in the ...
Sub Developmental Biology +3 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Protocol for identifying protein synthesis activity in specific cell types of the testicular lumen
STAR ProtocolsSummary: Protein synthesis could control spermatogenic cell fate transitions. Here, we present a protocol for visualization and quantification of newly synthesized proteins by click-chemistry-based immunofluorescence within specific spermatogenic cell ...
Dingfeng Zou +4 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
"Riding with the Wnt": Investigating the role of Wnt signaling in cell migration
, 2018 During my PhD, my goal was to achieve a better understanding of how animals develop from embryogenesis to adulthood. Specifically, I studied how cells acquire and control their movement to sculpt the final shape of an organism.
Rella, Lorenzo, Developmental Biology
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Genetic and optogenetic analysis of cell cleavage plane positioning
, 2020 Cells form the basis of life. Every animal starts its life as a single cell, which generates all the other cells of the body through repeated rounds of division. To develop properly, a fertilized egg needs to generate both adequate cell numbers and types.
Sub Developmental Biology +2 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
STAR ProtocolsSummary: Fertilized eggs initiate translation of stored mRNAs in spatially and temporally controlled manners. Here, we present a protocol for visualizing spatial and temporal translation in zebrafish embryos by fluorescence in situ hybridization and ...
Keisuke Sato, Tomoya Kotani
doaj +1 more source