Results 51 to 60 of about 602,081 (284)

OsRAD51C Is Essential for Double Strand Break Repair in Rice Meiosis

Frontiers in Plant Science, 2014
RAD51C is one of the RAD51 paralogs that plays an important role in DNA double-strand break repair by homologous recombination. Here, we identified and characterized OsRAD51C, the rice homolog of human RAD51C.
Ding eTang, Chunbo eMiao, Yafei eLi, Hongjun eWang, Xiaofei eLiu, Hengxiu eYu, Zhukuan eCheng   +6 more
doaj   +1 more source

POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis

Nature Communications, 2022
Cargo transport from the ER to the Golgi is highly selective. Here the authors identify three secretory pathway localized proteins that regulate ER sorting of receptor kinases in Arabidopsis and are required to support pollen tube growth.
Yong Xue, Jiang-Guo Meng, Peng-Fei Jia, Zheng-Rong Zhang, Hong-Ju Li, Wei-Cai Yang   +5 more
doaj   +1 more source

Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. [PDF]

, 2014
Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells.
Banerjee, Utpal, Evans, Cory J, Mondal, Bama Charan, Shim, Jiwon   +3 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Emx2 is an essential regulator of ciliated cell development across embryonic tissues

iScience
Summary: Cilia are hair-like organelles with vital physiological roles, and ciliogenesis defects underlie a range of severe congenital malformations and human diseases.
Thanh Khoa Nguyen, John-Michael Rodriguez, Hannah M. Wesselman, Rebecca A. Wingert   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice

iScience
Summary: Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone marrow.
Salli Talvi, Johanna Jokinen, Kalle Sipilä, Pekka Rappu, Fu-Ping Zhang, Matti Poutanen, Pia Rantakari, Jyrki Heino   +7 more
doaj   +1 more source

AAP Genetics Diagnostic Approach to Intellectual Disability or Global Developmental Delay

Pediatric Neurology Briefs, 2014
The American Academy of Pediatrics Committee on Genetics present a recommended clinical genetics diagnostic approach to the evaluation of intellectual disability or global developmental delays.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Evolutionary processes from the perspective of flowering time diversity. [PDF]

, 2020
Although it is well appreciated that genetic studies of flowering time regulation have led to fundamental advances in the fields of molecular and developmental biology, the ways in which genetic studies of flowering time diversity have enriched the field
Blackman, Benjamin K, Gaudinier, Allison
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source