Results 71 to 80 of about 602,081 (284)
iScience, 2020 Summary: Spermatogonial stem cells (SSCs) both self-renew and give rise to progenitors that initiate spermatogenic differentiation in the mammalian testis.
Keren Cheng +8 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Proteolysis regulates cardiomyocyte maturation and tissue integration
Nature Communications, 2017 Proper heart development and synchronous cardiomyocyte contraction rely on tissue integrity. Here the authors show that the ubiquitin-proteasome system and the E3 ubiquitin ligase ASB2 in particular are crucial for cardiomyocyte maturation and tissue ...
Ryuichi Fukuda +7 more
doaj +1 more source
Frontiers in Plant Science, 2016 The maintenance of leaf greenness in wheat, highly responsible for yield potential and resistance to drought stress, has been proved to be quantitatively inherited and susceptible to interact with environments by traditional genetic analysis. In order to
Delong eYang +6 more
doaj +1 more source
Achilles And The Tortoise: Some Caveats To Mathematical Modeling In Biology [PDF]
, 2018 Mathematical modeling has recently become a much-lauded enterprise, and many funding agencies seek to prioritize this endeavor. However, there are certain dangers associated with mathematical modeling, and knowledge of these pitfalls should also be part ...
Gilbert, Scott F.
core +3 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Evaluating the potential toxicity of ampicillin using Drosophila melanogaster as a model organism
Toxicology ReportsAntibiotic resistance is an indispensable threat facing in the present era. However, the studies on long term and trans-generational effects of using drugs or antibiotics on living organisms are scarce. Emphasizing the necessity to address such problems,
Asem Sanjit Singh +4 more
doaj +1 more source
Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
Nature Communications, 2018 There are two subtypes of hippocampal theta oscillations that differ in frequency range, pharmacology, and behavioural correlates. Here, the authors report that activity of OLM interneurons in the ventral hippocampus mediates type 2 theta, associated ...
Sanja Mikulovic +7 more
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A Stranger in a Strange Land: The Utility and Interpretation of Heterologous Expression
Frontiers in Plant Science, 2015 One of the major goals of the modern study of evodevo is to understand the evolution of gene function across a range of contexts, including sub/neofunctionalization, co-option of genetic modules, and the evolution of morphological novelty. To these ends,
Elena M Kramer
doaj +1 more source
Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]
, 2019 Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob +12 more
core +1 more source