Results 171 to 180 of about 607,896 (311)

Effects of developmental stage-driven fungal community shifts on biomass and metabolite accumulation in Gastrodia elata. [PDF]

Environ Microbiome
Zhang ZY, Wei GF, Hou LY, Zhang GZ, Li XD, Li M, Meng L, Wu GY, Xu J, Zhou YX, Sun C, Dong LL.   +11 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila. [PDF]

Nucleic Acids Res
Boutet T, Sakr R, Marzullo M, Goyal M, Cattenoz PB, Ciapponi L, Mukherjee T, Giangrande A.   +7 more
europepmc   +1 more source

Developmental Milestones, Stages [PDF]

, 2011
Leesa V. Huang, Sarah Woodrow
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

KMT2A-rearranged B-lymphoblastic lymphomas are skewed towards a more mature developmental stage. [PDF]

Leukemia
Iaccarino I, Hartmann AM, Yalcin F, Mondal M, Bozzetti C, Wolgast N, Loeffen JLC, Boer JM, Brüggemann M, Baldus CD, Cario G, Klapper W.   +11 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Leaf Developmental Stage Influences Disease Resistance in Tomato. [PDF]

Mol Plant Pathol
Lindner N, Leibman-Markus M, Gupta R, Anand G, Marash I, Dolgov T, Kleiman M, Bar M.   +7 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Nutrient Deprivation in <i>Artemia franciscana</i>: Developmental Stage, Nutritional History, and Phenotypes Linked to Conserved Pathways. [PDF]

Int J Mol Sci
Mitovic N, Stamatoski MM, Ilic D, Makki DY, Alsaadi H, Puflovic D, Milosevic M, Jovanovic M, Nale MM, Gostiljac D.   +9 more
europepmc   +1 more source