Results 241 to 250 of about 607,896 (311)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Developmental stage-specific transcriptomics of the hypothalamus-pituitary-testis axis reveals gene networks governing testicular maturation in Xianghuang chickens. [PDF]

Poult Sci
Ouyang Q, Li J, Song Y, Xiao J, Song Z, He X, Zhang H.   +6 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Host Developmental Stage and Vegetation Type Govern Root EcM Fungal Assembly in Temperate Forests. [PDF]

J Fungi (Basel)
Zhao DX, Wei YL, You ZQ, Bai Z, Yuan HS.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Seasonal and developmental stage changes in mucilage carbohydrate content shape the kelp microbiome. [PDF]

ISME Commun
English CJ, Manoj M, Henderson LC, Opalk K, Carlson CA.   +4 more
europepmc   +1 more source

Developmental stage and cellular context determine oncogenic and molecular outcomes of <i>Ezh2</i> ^Y641F mutation in hematopoiesis. [PDF]

Blood Neoplasia
Zimmerman SM, Procasky SJ, Smith SR, Liu JY, Torrice C, Souroullas GP.   +5 more
europepmc   +1 more source

Comparative Analysis of Microbial Communities in Each Developmental Stage of <i>Dermacentor nuttalli</i> in Two Regions in Inner Mongolia, China. [PDF]

Biology (Basel)
Zhao L, Dong XN, Cui H, Sun LY, Mu R, Nie M, Kang JM, Bu N, Zhang YS, Qi ZH, Li ZX, Zhang ZL, Zhang XY, Ding YL, Wang R, Wang Y, Liu YH.   +16 more
europepmc   +1 more source