Results 111 to 120 of about 541,021 (314)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Comparative molecular function, biological process and cellular component GO terms of stage-specific HcESP interacting proteins at different developmental stages and shared among all developmental stages.

, 2016
Comparative molecular function, biological process and cellular component GO terms of stage-specific HcESP interacting proteins at different developmental stages and shared among all developmental stages.
LiXin Xu (3145221), Javaid Ali Gadahi (3145215), XiangRui Li (3145224), Muhammad Ehsan (2561170), XiaoKai Song (677815), Gao Bo (3145218), Shuai Wang (109515), RuoFeng Yan (677814)   +7 more
core   +1 more source

Estimating the development of landrace and improved maize cultivars as a function of air temperature

Ciência Rural
: The objective of this study was to determine the maximum development rates for the phases of emergence, vegetative and reproductive, and to test the performance of the Wang and Engel (WE) model for simulating the development of landrace and improved ...
Josana Andreia Langner, Nereu Augusto Streck, Genei Antonio Dalmago, Lia Rejane Silveira Reiniger, Angelica Durigon, Stefanía Dalmolin da Silva, Isabel Lago, Lúcio Gabriel Scheffel, Anderson Haas Poersch   +8 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Yolk consumption rate during the 7 developmental stages.

, 2018
A: Yolk consumption rate (cm3 day-1) of S. stellaris embryos during the 7 developmental stages. Lines show mean ± SD (n = 8), while points show measurements from each individual.
Holly A. Shiels (344971), Syafiq M. Musa (5938121), Molly V. Czachur (5938124)   +2 more
core   +1 more source

Nationwide Library Consortia Life Cycle [PDF]

, 2003
Library consortia development processes were examined from an ecological approach, combining historical perspective, dynamic developmental approach, and social structure, stressing the issues of permeable boundaries in library consortia and the ...
Shachaf, Pnina
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Simple Categorization of Human Figure Drawings at 5 Years of Age as an Indicator of Developmental Delay

, 2019
Purpose: To elucidate the association between developmental stage of human figure drawing(HFD) and fine motor control, visual perception, and further investigate its potential to be used for screening developmental delay.
Smedler, AC, Tükel, Şermin, Smedler, Ann-Charlotte,, Eliasson, A. C., Bohm, B, Tükel, Şermin,, Tukel, S., Böhm, Birgitta,, Eliasson, Ann-Christin,, Smedler, A. C., Smedler, Ann Charlotte,, Tukel, S, Eliasson, AC, Bohm, B.   +13 more
core   +1 more source