Results 51 to 60 of about 15,996 (294)
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Japan – China: Official Development Assistance as a Tool of Economic Interaction [PDF]
Prostranstvennaâ Èkonomika, 2012 The paper deals with the outstanding role and implications of Japan’s ODA to the People’s Republic of China in the bilateral relations from the early 1980s till its termination in the 2000s.
Eugene Borisovich Kovrigin
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
DEVELOPMENTAL LINGUISTICS [PDF]
Folia Linguistica, 1981 This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Developmentalism, Bonapartism and populism: debates
Revista Mundos do Trabalho, 2017 This article analyses the different approaches to the Vargas Era proposed in recent works that emphasize Vargas as an epic of an injustified national hero, as Bonapartism and as a manifestation of a national-developmentalist project.
Murilo Leal Pereira Neto
doaj +1 more source
Changes of perspective introduced by Rousseau in educational practice [PDF]
, 2013 This paper is an attempt to discuss Rousseau’s ideas on educational practice through his book, Emile, arguably one of the most noteworthy books on education available today.
Goncalves, Marcus
core +1 more source