Results 51 to 60 of about 4,932 (298)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Plato on the Mechanics of Koinōnia Formation
Areté, 2022 This paper argues that, in order to understand the unified relations that are commonly predicated of koinōnia in the ethical, political, and cosmological spheres respectively, one must first appreciate certain prerequisite “principles” or “rules” that ...
Stephanos Stephanides
doaj +1 more source
Authoritarian developmentalism: The latest stage of neoliberalism? [PDF]
, 2021 We are amidst what can be termed an ongoing authoritarian turn in global politics. While Trump, one of its important examples, is no longer in office in the United States, there remain many countries under the sway of authoritarian leaders, such as ...
Arsel, Murat +3 more
core +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Transformasi Gender: Strategi Pembebasan Perempuan dari Jerat Pembangunan dan Kapitalisme
Sawwa: Jurnal Studi Gender, 2019 Indonesia has long been aware of the importance of gender equality through accommodating women's public rights and recognizing the importance of women's position in development.
Nurus Shalihin, Firdaus Firdaus
doaj +1 more source
New developmentalism in Brazil? The need for sectoral analysis [PDF]
, 2017 This article provides an analysis of the uneven practices and outcomes of new developmentalism in Brazil. New developmentalism has been described as a hybrid approach to development.
Salles Periera dos Santos, Rodrigo +4 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Rethinking agency: developmentalism, gender and rights
, 2013 In a new book, LSE’s Sumi Madhok proposes a new theoretical framework for agency thinking by examining the ethical, discursive and practical engagements of a group of women development workers in north-west India with developmentalism and individual ...
South Asia, LSE, Madhok, Sumi
core +5 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source