Results 31 to 40 of about 4,750,460 (270)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Unraveling the genetic traits and functional diversity of the pan-genome in Pantoea dispersa
BMC GenomicsBackground Medical devices are crucial in modern healthcare, but commonly used clinical tools such as cotton swabs can be easily contaminated by microorganisms (such as Pantoea), becoming vectors for pathogens and leading to patient infections or more ...
Shiyao He +7 more
doaj +1 more source
International Journal of Behavioral Nutrition and Physical Activity, 2020 Background Sedentary behaviour (SB) is a risk factor for chronic disease and premature mortality. While many individual studies have examined the reliability and validity of various self-report measures for assessing SB, it is not clear, in general, how ...
Stephanie A. Prince +7 more
doaj +1 more source
, 1976 An electrical filter for removing noise from a voice communications signal is reported; seven sample values of the signal are obtained continuously, updated and subjected to filtering.
Edwards, T. R., Zeanah, H. W.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Temporalités, 2010 If no area of research can avoid resetting the life stories being studied in their context, the issue becomes exemplary in the specific field of the sociology of migrations.
Piero-D. Galloro +2 more
doaj +1 more source
, 1979 An interleaving device for processing energy signals between various logic devices has a first number of spaced energy carrying layer mateials. Each of the first layer materials has a number of juxtaposed conduits passing energy signals through which are
Fischer, J. R.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Des jardins artificiels par d'autres stimuli que purement visuels
Projets de Paysage, 2010 The current trends for hybridization between natural and artificial associated with the loss of control of the city's architecture at large scale lead us to rethink the notion of contemporary garden.
Laurence Kimmel
doaj +1 more source
, 1975 A latching device is suited for use in establishing a substantially motionless connection between a stationary receiver and a movable latching mechanism.
Ulrich, G. W.
core +1 more source