Results 41 to 50 of about 831,296 (284)

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Davids versus Goliaths: Pharma and academia threats to individual scientists and clinicians

The Journal of Scientific Practice and Integrity, 2022
# Background We previously described experiences of clinicians who published adverse drug reaction reports. We now report on threats and intimidations leveled against clinicians and scientists who received publicly documented threats after communicating
Charles L. Bennett, Nancy Olivieri, Shamia Hoque, David Aboulafia, Anne Ventrone, Courtney Lubaczewski, Betty Dong, Benjamin Schooley, Bartlett J. Witherspoon, Paul S. Ray, William J. Hrushesky, John Restaino, Henrik S. Thomsen, Dennis Mangano, Christina Mora-Mangano, June M. McKoy, Martin Schoen, Kevin Knopf, Linda Martin, Steven Rosen   +19 more
doaj   +1 more source

A Cost-Effective Pulse Oximeter Designed in Response to the COVID-19 Pandemic

Journal of Open Hardware, 2021
This paper introduces the design of a small and cost-effective optical pulse oximeter, including a finger clip, sensor readout electronics, and associated firmware.
Benjamin Metcalfe, Pejman Iravani, Jonathan Graham-Harper-Cater, Richard Bowman, Julian Stirling, Peter Wilson   +5 more
doaj   +1 more source

A multisite study of performance drivers among institutional review boards. [PDF]

, 2017
Introduction:The time required to obtain Institutional Review Board (IRB) approval is a frequent subject of efforts to reduce unnecessary delays in initiating clinical trials. This study was conducted by and for IRB directors to better understand factors
Allen, Karen, Buscher, Nate, Caligiuri, Michael, Denney, Lisa, Firestein, Gary S, Fontanesi, John, Gates, Cynthia, Kantelo, Kip, Magit, Anthony, Sak, Rachael   +9 more
core   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Seeking a common human factors language for the development and testing of injection devices

Drug Delivery
Injection devices include drug–device combination products incorporating a needle for subcutaneous medication delivery. Often utilized by patients and caregivers, it is important for injection device user interface (UI) design to be intuitive to use ...
Megan O. Conrad, Molly E. Laird, Mary Beth Privitera, Melissa R. Lemke, Molly Follette Story   +4 more
doaj   +1 more source

Pivotal trials of orthopedic surgical devices in the United States: predominance of two-arm non-inferiority designs

Trials, 2017
Background The United States Food and Drug Administration (FDA) reviews class III orthopedic devices submitted for premarket approval with pivotal clinical trials.
S. Raymond Golish
doaj   +1 more source

Radiotherapy Delivery in Deep Inspiration for Pediatric Patients—Final Results of the Phase II Feasibility Study TEDDI

Pediatric Blood &Cancer, EarlyView.
Abstract Introduction The TEDDI trial tested the feasibility and reproducibility of deep‐inspiration breath‐hold (DIBH) in pediatric patients referred for radiotherapy. This report presents final results, including patient‐reported outcomes (PRO) and dosimetric comparison of DIBH and free‐breathing (FB).
Daniella Elisabet Østergaard, Anni Young Lundgaard, Laura Ann Rechner, Danijela Dejanovic, Hanne Krogh Rose, Jolanta Hansen, Leila Vaalavirta, Miia Mokka, Marianne Aznar, Peder Skov Wehner, Lisa Lyngsie Hjalgrim, Maja Vestmø Maraldo   +11 more
wiley   +1 more source

Trigeminal nerve stimulation: a recently approved treatment approach in attention deficit hyperactivity disorder

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Attention-deficit hyperactivity disorder (ADHD) with its high prevalence is a growing area of concern and research, whereas exact underlying pathophysiology remains unknown. Behavioral therapy and multiple medications include methylphenidate, atomoxetine,
Mazlum Çöpür, Sidar Çöpür
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source