Results 41 to 50 of about 2,408,202 (289)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Diagnosis of Cardiac Device–Related Infective Endocarditis After Device Removal [PDF]

, 2010
ObjectivesWe sought to determine the incidence, diagnostic value, and outcome of intracardiac masses observed by echocardiography after device removal. We hypothesized that these “ghosts” of leads could be associated with the diagnosis of cardiac device ...
Le Dolley, Yvan, Didier Raoult, Riberi, Alberto, Julien Mancini, Avierinos, Jean-François, Casalta, Jean-Paul, Prevot, Sebastien, Roch Giorgi, Ansaldi, Sebastien, Jean-Paul Casalta, Sebastien Ansaldi, Giorgi, Roch, Thuny, Franck, Jean-François Avierinos, Deharo, Jean-Claude, Yvan Le Dolley, Laurence Tafanelli, Emilie Bastard, Sebastien Prevot, Franceschi, Frederic, Alberto Riberi, Jean-Claude Deharo, Tafanelli, Laurence, Franck Thuny, Renard, Sebastien, Frederic Franceschi, Gilbert Habib, Sebastien Renard, Gouriet, Frédérique, Bastard, Emilie, Mancini, Julien, Habib, Gilbert, Raoult, Didier, Frédérique Gouriet   +33 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Management of Undeflatable Coronary Balloons During Percutaneous Coronary Intervention: A Case-Based Review and Practical Bailout Algorithm

Reviews in Cardiovascular Medicine
Background:Undeflatable coronary balloons during percutaneous coronary intervention (PCI) are rare but particularly hazardous because persistent intracoronary inflation can cause abrupt coronary occlusion, ischaemia, and haemodynamic collapse.
Allam Harfoush, Tammam Harfouch, Muntasir Abo-Al-Hayja, Khaled Albouaini, Ammar Ezeldin, Hanady Hamdallah, Abdalazeem Ibrahem   +6 more
doaj   +1 more source

Breakdown of complications related to the use of central venous catheters in intensive therapy units

Bioscience Journal, 2018
The ICU is a highly complex sector, and among the wide range of interventions performed in the intensive care patient, we highlight the use of the central venous catheter (CVC).
Jaciara Aparecida de Jesus Silva, Lúcia Aparecida Ferreira, Fernanda Bonato Zuffi, Marina Pereira Rezende, Guilherme Silva Mendonca   +4 more
doaj   +1 more source

In vitro characterization of PrismaLung+: a novel ECCO2R device

Intensive Care Medicine Experimental, 2020
Background Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury.
Ingeborg Hospach, Jacques Goldstein, Kai Harenski, John G. Laffey, Dominique Pouchoulin, Manuela Raible, Stefanie Votteler, Markus Storr   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Simulation of a mechanical thrombectomy device based in the use of self-expandable stents for the blood clots extraction [PDF]

, 2011
Recently, we have presented some studies concerning the analysis, design and optimization of one experimental device developed in the UK - GPTAD - which has been designed to remove blood clots without the need to make contact with the clot itself ...
Romero Rey, Gregorio, Martínez Muneta, María Luisa   +1 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source