Results 61 to 70 of about 2,408,202 (289)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 1981 The disclosure concerns a device suitable for removing air from water under both zero and one 'g' gravity conditions. The device is comprised of a pair of spaced membranes on being hydrophobic and the other being hydrophilic.
Booth, F. W., Bruce, R. A.
core
Biological excess phosphorus removal in activated sludge systems [PDF]
, 1988 Includes bibliographies.When this investigation was commenced in 1983 two activated sludge systems had been developed in South Africa that accomplish biological excess phosphorus (P) removal, the UCT and modified Bardenpho systems.
Wentzel, Mark Charles
core +1 more source
Medical SciencesBackground: Explantation after chimney, fenestrated, or branched endovascular aortic repair is technically demanding because major arterial branches are incorporated into the device.
Luis O. Bobadilla-Rosado +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Foot & Ankle Orthopaedics, 2019 Category: Trauma Introduction/Purpose: Suture-button fixation device (TightRope, Arthrex, Naples, Florida) is devised to obviate the need for second operation for removal in the treatment of syndesmosis diastasis, but considerable removal rate has been ...
Jae Young Kim MD, Jaeho Cho MD, PhD
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Nitrate removal in a restored riparian groundwater system : functioning and importance of individual riparian zones [PDF]
, 2012 For the design and the assessment of river restoration projects, it is important to know to what extent the elimination of reactive nitrogen (N) can be improved in the riparian groundwater.
Tockner, Klement +26 more
core +2 more sources
DESIGN AND ANALYSIS OF AN INNER BURR REMOVAL DEVICE IN LONGITUDINALLY WELDED PIPE
Jixie qiangdu, 2022 The application field of longitudinally welded pipe is expanding day by day, and its quality requirements are increasing.The inner burr removal device, as a key equipment to improve the quality of the inner surface of the longitudinally welded pipe, has ...
HOU YuLei +3 more
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