Results 221 to 230 of about 269,360 (302)

Human biomarker navigator

open access: yesiMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li   +29 more
wiley   +1 more source

Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity

open access: yesInterdisciplinary Medicine, EarlyView.
Vaginal microbiota‐derived secretory factors enhance the regenerative capacity of human endometrial stem cells by upregulating VCAM1 and activating PI3K/Akt signaling. This microbiota–stem cell crosstalk promotes self‐renewal, migration, multilineage differentiation, and metabolic reprogramming in vitro and in vivo, establishing a novel microbiota ...
Soo‐Rim Kim   +6 more
wiley   +1 more source

Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress–related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX‐induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX‐associated redox
Caner Öztürk   +4 more
wiley   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang   +5 more
wiley   +1 more source

Prognostic Significance of Peripheral Blood Neutrophil‐To‐Lymphocyte Ratio (NLR), Monocyte‐To‐Lymphocyte Ratio (MLR), and Platelet‐To‐Lymphocyte Ratio (PLR) in Patients With Multiple Myeloma: A Retrospective Cohort Study

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract illustrates the prognostic significance of systemic inflammatory markers in Multiple Myeloma (MM). The left panel depicts the immunosuppressive tumor microenvironment, where abundant neutrophils and M2 macrophages promote MM cell survival while lymphocytes are depleted.
Lihong Zhang, Bing Ma, Jingyu Zhang
wiley   +1 more source

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