Results 281 to 290 of about 510,342 (390)

Catalyst‐Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds

Advanced Science, EarlyView.
A bioorthogonal rhodamine/PEG crosslinking strategy is introduced to engineer dense collagen hydrogels with high mechanical resilience and cytocompatibility. Integration with wet‐spinning enables the fabrication of uniaxially aligned, cell‐laden collagen filaments that activate mechanotransductive signaling and support functional muscle regeneration in
JuYeon Kim, Hanjun Hwangbo, ByungJoon Choi, Dogeon Yoon, GeunHyung Kim   +4 more
wiley   +1 more source

Beyond the Classical Axis: Metabolic "Pressure" on the Adrenal Gland? [PDF]

Diabetes
Isidori AM, Pofi R, Fleseriu M.
europepmc   +1 more source

Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM.

Blood, 2016
A. Jakubowiak, Michael D. Robbins, A. Palumbo   +2 more
semanticscholar   +1 more source

Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization

Advanced Science, EarlyView.
Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu, Xuechun Yu, Yanling Li, Lin An, Rongrong Zhang, Rong Zhang, Fan Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Benefits of Steroid Injections into Paraspinous Muscles After Spinal Surgery in a Rat Paraspinal Muscle Retraction Model. [PDF]

Int J Mol Sci
Sheu ML, Pan LY, Sheehan J, Lai DW, Chou YC, Pan LY, Wang CC, Chen YJ, Su HL, Tsou HK, Pan HC.   +10 more
europepmc   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Optimizing antenatal corticosteroid therapy for improving outcome of premature infants. [PDF]

, 2019
A Donaldson, Augusto F. Schmidt, CL Elliott, D Roberts, E Asztalos, EP Davis, F Althabe, F Waffarn, GC Liggins, GC Liggins, HG Liley, JP Vogel, Kristi L. Watterberg, M Della Torre, P Ballabh, Philip L. Ballard, PL Ballard, PL Ballard, RS Egerman, SE Tsuei   +19 more
core   +1 more source

Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma.

New England Journal of Medicine, 2007
Jaya Ghosh, Lalit Kumar, M. Dimopoulos, A. Spencer, Miles MICHAEL ATTAL, Deepak Dabkara, Jyoti Bajpai   +6 more
semanticscholar   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Dexamethasone inhibits Mycobacterium tuberculosis-induced glycolysis but preserves antimicrobial function in primary human macrophages. [PDF]

Sci Rep
Thong L, Sandby Thomas O, Ó Gallchobhair O, Duffin E, Yennemadi AS, Leisching G, Murphy DM, Nadarajan P, O'Connell F, O'Sullivan MP, Basdeo SA, Cox DJ, Keane J.   +12 more
europepmc   +1 more source