Results 291 to 300 of about 496,062 (355)

Tocilizumab Dosing for Management of T Cell‐Engaging Bispecific Antibody‐Related CRS in Patients With R/R B‐Cell NHL

Clinical Pharmacology &Therapeutics, EarlyView.
Tocilizumab dosing for management of T cell‐engaging bispecific antibody‐related CRS in patients with R/R B‐cell NHL. The recent surge in T‐cell‐engaging and chimeric antigen receptor (CAR) T‐cell therapies is changing the landscape of cancer therapy.
Candice Jamois, David C. Turner, Leonid Gibiansky, Feifei Li, Jean‐Francois Menuet, Leonardo Roque Pereira, Linda Lundberg, Elena Guerini, David J. Carlile, James Relf, Michael C. Wei, Antonia Kwan, Nicolas Frey, Susan Grange   +13 more
wiley   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Heat-Killed <i>Lactobacillus plantarum</i> beLP1 Attenuates Dexamethasone-Induced Sarcopenia in Rats by Increasing AKT Phosphorylation. [PDF]

Biomedicines
Choi J, Jeong E, Park H, Song HY, Moon J, Kim MA, Koo BS, Lee JH, Hong JK, Han KI, Kim D, Kim HS, Kim TJ.   +12 more
europepmc   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Dexamethasone induces transgenerational inheritance of fetal-derived glomerulosclerosis phenotype in offspring through GR/DNMT3a mediated alterations of the lncRNA-Meg3/Notch signaling pathway. [PDF]

Cell Commun Signal
Zhao X, Wang Z, Xia Z, Chen H, Zhu Y, Wang S, Bao Y, Liu Y, Wang H, Ao Y.   +9 more
europepmc   +1 more source

Exploring the Potential of Tsuruazuki Bean as a Functional Food to Curb Obesity Using Human Amniotic Epithelial Cells and 3T3‐L1 Preadipocytes

Food Frontiers, EarlyView.
Obesity is a global health problem that requires research and regulatory attention. This research aims to investigate transcriptome‐wide changes induced by Vigna umbellata (Tsuruazuki) using a stem cell‐based tool and preadipocytes to explore its untapped potential as a functional food for anti‐obesity applications.
Elda Nurafnie Ibnu Rasid, Farhana Ferdousi, Kazunori Sasaki, Kyoko Toda, Shinya Takahashi, Mari Maeda‐Yamamoto, Hiroko Isoda   +6 more
wiley   +1 more source

Astragalus Polysaccharide Alleviates COPD‐Associated Skeletal Muscle Dysfunction Through Suppression of Inflammation and Cellular Senescence

Food Frontiers, EarlyView.
APS alleviates COPD‐associated skeletal muscle dysfunction in both animal and cellular models. This study provides compelling preclinical evidence supporting APS as a promising functional food ingredient for mitigating skeletal muscle wasting in COPD. ABSTRACT Astragalus polysaccharide (APS) exhibits various pharmacological properties.
Yan Mou, Yunhuan Liu, Yanjuan Chen, Ruling Shen, Aoxue Yan, Tongtong Liao, Yanyin Liu, Hejun Su, Zhenming He, Yue Wang, Lin Qi, Huili Zhu, Haiyan Ge   +12 more
wiley   +1 more source

Effect of dexamethasone on rebound pain and analgesic effects after upper limb surgery under brachial plexus block: a meta-analysis. [PDF]

BMC Surg
Qian C, Wei X, Zhang J, Zhao Y, Li S, Wang Z.   +5 more
europepmc   +1 more source

Anti‐Inflammatory Effects of Flavonoids in Otitis Media: A Systematic Review of Pre‐Clinical Evidence

Food Frontiers, EarlyView.
Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz, Ayesha Zahid, Hazrat Ismail, Misbah Ajaz   +3 more
wiley   +1 more source

Cetuximab Hypersensitivity in the Setting of Asymptomatic Alpha‐Gal Sensitization

Head &Neck, EarlyView.
ABSTRACT Background Alpha‐gal syndrome is an allergic condition resulting from the bite of the Lonestar tick in the southeastern US that leads to sensitization to mammalian products containing the oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal).
Alexander G. Emerson, Lindsay Mundy, Barbara A. Murphy, Cosby A. Stone   +3 more
wiley   +1 more source