Results 41 to 50 of about 269,360 (302)

Dexamethasone-induced expression of ZED1^‘DT’ (N173D V212T) causes whole-plant HR in Arabidopsis.

, 2019
BASTA-resistant Arabidopsis transformants bearing dexamethasone-inducible ZED1 alleles (columns 4–7) were tested alongside control plants (columns 1–3; untransformed Col-0, transgenic plants with dexamethasone-inducible AvrRpt2, and untransformed zar1-1).
André Santos-Severino (6911966), Alexandre Martel (6559460), Jianfeng Zhang (219107), David S. Guttman (131322), Wardah Masud (6911963), Jee Yeon Lee (5489246), Derek Seto (6911960), D. Patrick Bastedo (5489255), Inga Kireeva (2460394), Amy Huei-Yi Lee (185662), Yunchen Gong (109044), Darrell Desveaux (69192), Madiha Khan (6758228), David Millar (1806088)   +13 more
core   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: Updated analysis of POLLUX

, 2018
In the POLLUX study, daratumumab plus lenalidomide/dexamethasone significantly reduced risk of progression/death versus lenalidomide/ dexamethasone alone in relapsed/refractory multiple myeloma. We provide one additional year of follow up and include the
Cochrane, T, Leiba, M, Joy Ho, P, San-Miguel, J, White, D, Kaufman, JL, Morton, J, Takezako, N, Belch, A, Cook, G, Dimopoulos, MA, Benboubker, L, Moreau, P, Kim, K, et al.   +14 more
core   +1 more source

A Novel Drug‐Loaded Porous Parylene Electrode for Targeted Anti‐Inflammatory Therapy and Hearing Preservation in Cochlear Implantation

Advanced Healthcare Materials, EarlyView.
A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang, Ying‐Chang Lu, Yu‐Ming Chang, Yen‐Hui Chan, Hong‐Yu Yan, Yi‐Shan Lee, Pei‐Hsuan Lin, Cheng‐Yu Hsieh, Chuan‐Jen Hsu, Tien‐Chen Liu, Hsien‐Yeh Chen, Chen‐Chi Wu   +11 more
wiley   +1 more source

Effects of Dexamethasone on Interleukin-6 and Immunoglobulins Production by Lamina Propria Mononuclear Cells Isolated from Biopsy Specimens in Patients with Ulcerative Colitis [PDF]

, 1994
Lamina propria mononuclear cells (LPMNC) were isolated from 20 untreated patients with active ulcerative colitis (UC) and 11 patients with inactive UC. All patients with active UC were first attacks, and were not being treated with any drugs. The effects
Oda, Hidetoshi, Senju, Masahiro, Makiyama, Kazuya, Nakamuta, Koji, Yamasaki, Yoshiyuki, Kanzaki, Shinichiro   +5 more
core  

Dexamethasone-Enhanced Continuous Online Microdialysis for Neuromonitoring of O₂ after Brain Injury

, 2023
Traumatic brain injury (TBI) is a major public health crisis in many regions of the world. Severe TBI may cause a primary brain lesion with a surrounding penumbra of tissue that is vulnerable to secondary injury.
Andrea S. Jaquins-Gerstl (9089581), Martyn G. Boutelle (1362306), Adrian C. Michael (1335324), Elaine M. Robbins (16456086), David O. Okonkwo (3816115)   +4 more
core   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

The efficacy of premedication with 10 mg versus 20 mg of intravenous dexamethasone for prevention of paclitaxel hypersensitivity reaction in low-risk gynecologic cancer patients: a non-inferiority, randomized controlled mono-institutional trial

BMC Cancer
Background Dexamethasone has been used extensively to prevent hypersensitivity reactions to paclitaxel. However, the optimal dose of dexamethasone is controversial, varying between 20 mg and 10 mg.
Nutthakarn Sa-ngiamphorn, Prapaporn Suprasert, Chaiyut Charoentum   +2 more
doaj   +1 more source

Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis

Acta Veterinaria Scandinavica, 2019
Background Dexamethasone is used for the intra-articular route of administration in management of aseptic arthritis in horses. Despite its widespread use there is very little quantitative data of the disposition and response to dexamethasone.
Carl Ekstrand, Ulf Bondesson, Ellen Giving, Mikael Hedeland, Carina Ingvast-Larsson, Stine Jacobsen, Maria Löfgren, Lars Moen, Marie Rhodin, Tonje Saetra, Birgit Ranheim   +10 more
doaj   +1 more source

IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1 beta [PDF]

, 2007
To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Macrae, V.E., Ahmed, S Faisal, Ahmed, S.F., Mushtaq, Talat, Farquharson, C., Farquharson, Colin; id_orcid, Macrae, Vicky E, Mushtaq, T.   +7 more
core   +1 more source