Results 31 to 40 of about 277,227 (258)

Nanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs

Pharmaceutics
Background/Objectives: Glioblastoma is the most common and lethal primary brain tumor. Patients often suffer from tumor- and treatment induced vasogenic edema, with devastating neurological consequences.
Demian van Straten, Jaime Fernández Bimbo, Wim E. Hennink, Tina Vermonden, Raymond M. Schiffelers   +4 more
doaj   +1 more source

Supplemental Data Dexamethasone Suppression Free Cortisol

, 2021
Supplemental Figure 1: Total and free cortisol after dexamethasone suppression test versus dexamethasone suppression test in volunteers. Vertical line demarcates the bottom 2.5% of all dexamethasone values in volunteers.Supplemental Figure 2: Free ...
Natalia Genere (11022501)
core   +1 more source

Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction

Life, 2021
Cancer stem cells (CSCs) have high tumor-initiating capacity and are resistant to chemotherapeutic reagents; thus eliminating CSCs is essential to improving the prognosis.
Shuhei Suzuki, Masahiro Yamamoto, Tomomi Sanomachi, Keita Togashi, Asuka Sugai, Shizuka Seino, Takashi Yoshioka, Masashi Okada, Chifumi Kitanaka   +8 more
doaj   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

The protective Effect of Nigella sativa on sperm parameter in mice treated with dexamethasone

مجله علمی دانشگاه علوم پزشکی کردستان, 2020
Background and Aim: Dexamethasone affects testis hemostasis through reduction of  testosterone level . In one study dexamethasone induced spermatogenesis defects through epithelial vacuolizations and sloughing of germ cell layer.
saeid miri, morteza abouzaripour, Mohammad Jafar Rezaie, Fardin Fathi, bahram nikkho, daem roshani, shiva khalesro, Erfan daneshi   +7 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring [PDF]

, 1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying this link are unknown but fetal exposure to excess glucocorticoids has been implicated, The fetus is normally protected from ...
Kenyon, C J, Seckl, J R, C J Kenyon, Burchell, A, R S Lindsay, A Burchell, J R Seckl, Lindsay, R S, M J Nyirenda, Nyirenda, M J   +9 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Dexamethasone-regulated Gene Signature Is Prognostic for Poor Survival in Glioblastoma Patients. [PDF]

, 2017
BACKGROUND Dexamethasone is reported to induce both tumor-suppressive and tumor-promoting effects. The purpose of this study was to identify the genomic impact of dexamethasone in glioblastoma stem cell (GSC) lines and its prognostic value ...
Hatami, Masumeh, Jennifer C. Mosley, Luedi, Markus M, Erik P. Sulman, Zinn, Pascal O, Frederick F. Lang, Sulman, Erik P, Lang, Frederick F, Frank Stueber, Joy Gumin, Colen, Rivka R, Rivka R. Colen, Stueber, Frank, Sanjay K. Singh, Singh, Sanjay K, Masumeh Hatami, Gumin, Joy, Mosley, Jennifer C, Markus M. Luedi, Pascal O. Zinn, Hatami M, Lang FF, Stueber F, Mosley JC, Gumin J, Sulman EP, Luedi MM, Zinn PO, Colen RR, Singh SK   +29 more
core   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source