Results 31 to 40 of about 250,188 (305)

Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction

Life, 2021
Cancer stem cells (CSCs) have high tumor-initiating capacity and are resistant to chemotherapeutic reagents; thus eliminating CSCs is essential to improving the prognosis.
Shuhei Suzuki, Masahiro Yamamoto, Tomomi Sanomachi, Keita Togashi, Asuka Sugai, Shizuka Seino, Takashi Yoshioka, Masashi Okada, Chifumi Kitanaka   +8 more
doaj   +1 more source

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring [PDF]

, 1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying this link are unknown but fetal exposure to excess glucocorticoids has been implicated, The fetus is normally protected from ...
Kenyon, C J, Seckl, J R, C J Kenyon, Burchell, A, R S Lindsay, A Burchell, J R Seckl, Lindsay, R S, M J Nyirenda, Nyirenda, M J   +9 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The protective Effect of Nigella sativa on sperm parameter in mice treated with dexamethasone

مجله علمی دانشگاه علوم پزشکی کردستان, 2020
Background and Aim: Dexamethasone affects testis hemostasis through reduction of  testosterone level . In one study dexamethasone induced spermatogenesis defects through epithelial vacuolizations and sloughing of germ cell layer.
saeid miri, morteza abouzaripour, Mohammad Jafar Rezaie, Fardin Fathi, bahram nikkho, daem roshani, shiva khalesro, Erfan daneshi   +7 more
doaj  

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Dexamethasone-induced expression of ZED1^‘DT’ (N173D V212T) causes whole-plant HR in Arabidopsis.

, 2019
BASTA-resistant Arabidopsis transformants bearing dexamethasone-inducible ZED1 alleles (columns 4–7) were tested alongside control plants (columns 1–3; untransformed Col-0, transgenic plants with dexamethasone-inducible AvrRpt2, and untransformed zar1-1).
André Santos-Severino (6911966), Alexandre Martel (6559460), Jianfeng Zhang (219107), David S. Guttman (131322), Wardah Masud (6911963), Jee Yeon Lee (5489246), Derek Seto (6911960), D. Patrick Bastedo (5489255), Inga Kireeva (2460394), Amy Huei-Yi Lee (185662), Yunchen Gong (109044), Darrell Desveaux (69192), Madiha Khan (6758228), David Millar (1806088)   +13 more
core   +1 more source

IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1 beta [PDF]

, 2007
To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Macrae, V.E., Ahmed, S Faisal, Ahmed, S.F., Mushtaq, Talat, Farquharson, C., Farquharson, Colin; id_orcid, Macrae, Vicky E, Mushtaq, T.   +7 more
core   +1 more source

Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Individuals with systemic lupus erythematosus (SLE) can accumulate functional status (FS) impairment. We evaluated the association between neighborhood socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), and FS in a national SLE sample.
Baljeet Rai, Jessica Fitzpatrick, Jing Li, Eric Roberts, Patricia Katz, Laura Plantinga, Gabriela Schmajuk, Jinoos Yazdany   +7 more
wiley   +1 more source

Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: Updated analysis of POLLUX

, 2018
In the POLLUX study, daratumumab plus lenalidomide/dexamethasone significantly reduced risk of progression/death versus lenalidomide/ dexamethasone alone in relapsed/refractory multiple myeloma. We provide one additional year of follow up and include the
Cochrane, T, Leiba, M, Joy Ho, P, San-Miguel, J, White, D, Kaufman, JL, Morton, J, Takezako, N, Belch, A, Cook, G, Dimopoulos, MA, Benboubker, L, Moreau, P, Kim, K, et al.   +14 more
core   +1 more source