Results 11 to 20 of about 250,188 (305)

Baricitinib plus dexamethasone compared to dexamethasone for the treatment of severe COVID-19 pneumonia: A retrospective analysis

Journal of Microbiology, Immunology and Infection, 2021
Objective: We aimed to analyze clinical outcomes from patients with severe COVID-19 pneumonia that received either baricitinib plus dexamethasone or dexamethasone monotherapy. Methodology: We performed a retrospective comparative study.
Eduardo Pérez-Alba, Laura Nuzzolo-Shihadeh, Gloria Mayela Aguirre-García, Jaime Espinosa-Mora, Juan Diego Lecona-Garcia, Romulo Omar Flores-Pérez, Marisela Mendoza-Garza, Adrián Camacho-Ortiz   +7 more
doaj   +1 more source

Prunetin Protects Against Dexamethasone-Induced Pancreatic Β-Cell Apoptosis via Modulation of p53 Signaling Pathway

Natural Product Communications, 2020
Long-term administration of dexamethasone results in insulin resistance and pancreatic β-cell apoptosis. Prunetin (an O -methylated isoflavone, a type of flavonoid) is demonstrated to protect diabetes, but the molecular mechanism of this protection is ...
Suwattanee Kooptiwut, Kanokwan Samon, Namoiy Semprasert, Kanchana Suksri, Pa-Thai Yenchitsomanus   +4 more
doaj   +1 more source

The Efficacy of High-Dose Dexamethasone vs. Other Treatments for Newly Diagnosed Immune Thrombocytopenia: A Meta-Analysis

Frontiers in Medicine, 2021
Objective: To compare the therapeutic efficacies of high dose dexamethasone, prednisone and rituximab in combination with dexamethasone for newly diagnosed ITP (Immune Thrombocytopenia, ITP) patients.Methods and results: Relevant publications for this ...
Qirong Xiao, Qirong Xiao, Bicun Lin, Bicun Lin, Hanyu Wang, Weiwu Zhan, Weiwu Zhan, Ping Chen, Ping Chen   +8 more
doaj   +1 more source

Dexamethasone Improves Cardiovascular Outcomes in Critically Ill COVID-19, a Real World Scenario Multicenter Analysis

Frontiers in Medicine, 2022
BackgroundSevere COVID-19 pneumonia requiring intensive care treatment remains a clinical challenge to date. Dexamethasone was reported as a promising treatment option, leading to a reduction of mortality rates in severe COVID-19 disease.
Peter Jirak, Vincent van Almsick, Dimitrios Dimitroulis, Moritz Mirna, Clemens Seelmaier, Zornitsa Shomanova, Bernhard Wernly, Bernhard Wernly, Bernhard Wernly, Dilvin Semo, Daniel Dankl, Magdalena Mahringer, Michael Lichtenauer, Uta C. Hoppe, Holger Reinecke, Rudin Pistulli, Robert Larbig, Robert Larbig, Lukas J. Motloch   +18 more
doaj   +1 more source

Analysis of renal impairment in MM-003, a phase III study of pomalidomide + low - dose dexamethasone versus high - dose dexamethasone in refractory or relapsed and refractory multiple myeloma

Haematologica, 2016
Pomalidomide + low-dose dexamethasone is effective and well tolerated for refractory or relapsed and refractory multiple myeloma after bortezomib and lenalidomide failure.
Katja C. Weisel, Meletios A. Dimopoulos, Philippe Moreau, Martha Q. Lacy, Kevin W. Song, Michel Delforge, Lionel Karlin, Hartmut Goldschmidt, Anne Banos, Albert Oriol, Adrian Alegre, Christine Chen, Michele Cavo, Laurent Garderet, Valentina Ivanova, Joaquin Martinez-Lopez, Stefan Knop, Xin Yu, Kevin Hong, Lars Sternas, Christian Jacques, Mohamed H. Zaki, Jesus San Miguel   +22 more
doaj   +1 more source

Immune and ionic mechanisms mediating the effect of dexamethasone in severe COVID-19

Frontiers in Immunology, 2023
IntroductionSevere COVID-19 is characterized by cytokine storm, an excessive production of proinflammatory cytokines that contributes to acute lung damage and death.
Ameet A. Chimote, Abdulaziz O. Alshwimi, Martina Chirra, Vaibhavkumar S. Gawali, Margaret V. Powers-Fletcher, Kristin M. Hudock, Kristin M. Hudock, Laura Conforti   +7 more
doaj   +1 more source

Comparison of Intravitreal Bevacizumab Upload Followed by a Dexamethasone Implant versus Dexamethasone Implant Monotherapy for Retinal Vein Occlusion with Macular Edema [PDF]

, 2012
Purpose: To compare the efficacy and safety of three intravitreal bevacizumab upload injections followed by a dexamethasone implant versus dexamethasone implant monotherapy in eyes with macular edema due to retinal vein occlusion.
Haritoglou, Christos, Mayer, Wolfgang J., Wolf, Armin, Kook, Daniel, Ulbig, Michael, Reznicek, Lukas, Remy, Matthias, Kampik, Anselm   +7 more
core   +1 more source

Dexamethasone enhances osteogenic differentiation of bone marrow- and muscle-derived stromal cells and augments ectopic bone formation induced by bone morphogenetic protein-2. [PDF]

PLoS ONE, 2015
UNLABELLED:We evaluated whether dexamethasone augments the osteogenic capability of bone marrow-derived stromal cells (BMSCs) and muscle tissue-derived stromal cells (MuSCs), both of which are thought to contribute to ectopic bone formation induced by ...
Masato Yuasa, Tsuyoshi Yamada, Takashi Taniyama, Tomokazu Masaoka, Wei Xuetao, Toshitaka Yoshii, Masaki Horie, Hiroaki Yasuda, Toshimasa Uemura, Atsushi Okawa, Shinichi Sotome   +10 more
doaj   +1 more source

The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression. [PDF]

, 2009
In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated. In 114 depressed inpatients suffering from unipolar or bipolar depression (sample 1) the DEX/CRH test was ...
Daniela Eser, Baghai Thomas C., Herrmann, Sascha, Rupprecht Rainer, Born, Christoph, Sascha Herrmann, Schüle Cornelius, Cornelius Schüle, Sibylle Häfner, Rupprecht, Rainer, Häfner Sibylle, Eser, Daniela, Schüle, Cornelius, Baghai, Thomas C., Herrmann Sascha, Christoph Born, Rainer Rupprecht, Thomas C. Baghai, Häfner, Sibylle, Thomas C Baghai, Eser Daniela, Born Christoph   +21 more
core   +1 more source

Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models.

PLoS ONE, 2019
IntroductionCombination therapy for acute lymphoblastic leukemia (ALL) is highly effective but results in significant toxicity including osteonecrosis.
Seth E Karol, Laura J Janke, John C Panetta, Laura B Ramsey, Xiangjun Cai, Monique A Payton, David A Jenkins, William E Evans, Mary V Relling   +8 more
doaj   +1 more source