Comparative efficacy of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists with or without dexamethasone for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy (HEC): a network meta-analysis [PDF]
PeerJObjective This network meta-analysis evaluated the efficacy of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists, with or without Dexamethasone (D), for preventing chemotherapy-induced nausea and vomiting (CINV) in patients undergoing highly emetogenic ...
Hongxia Xu +5 more
doaj +3 more sources
The Effect of the Timing of Dexamethasone Administration in Patients with COVID-19 Pneumonia [PDF]
Tuberculosis and Respiratory Diseases, 2021 Background Despite the proven benefits of dexamethasone in hospitalized coronavirus disease 2019 (COVID-19) patients, the optimum time for the administration of dexamethasone is unknown.
Hyun Woo Lee +4 more
doaj +1 more source
Acute Activation of Metabolic Syndrome Components in Pediatric Acute Lymphoblastic Leukemia Patients Treated with Dexamethasone. [PDF]
PLoS ONE, 2016 Although dexamethasone is highly effective in the treatment of pediatric acute lymphoblastic leukemia (ALL), it can cause serious metabolic side effects.
Lidewij T Warris +9 more
doaj +1 more source
Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]
PLoS ONE, 2018 INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
doaj +1 more source
BMJ Paediatrics Open, 2023 Background Dexamethasone is widely used as a systemic corticosteroid to treat and prevent bronchopulmonary dysplasia (BPD) in preterm infants. We evaluated the current epidemiology of dexamethasone use to prevent BPD and analyse the factors associated ...
Soon Min Lee +12 more
doaj +1 more source
Efficiency of a dexamethasone nanosuspension as an intratympanic injection for acute hearing loss
Drug Delivery, 2022 Dexamethasone sodium phosphate (Dex-SP) is the most commonly used drug administered via intratympanic injection for the treatment of acute hearing loss, but its penetration efficiency into the inner ear is very low.
So-Young Jung +7 more
doaj +1 more source
Open Medicine, 2022 Dexamethasone can be used to prevent nausea and vomiting after surgery, but there is concern that it may induced perineal irritation. The aim of this study was to investigate the attenuation effect of dilution and slow injection on dexamethasone-induced ...
Zhang Yonghai +8 more
doaj +1 more source
The Effect of Dexamethasone Treatment on COVID-19 Prognosis in Cancer Patients
Vaccines, 2022 Background: Dexamethasone is used to treat cancer, relieve chemotherapy-induced nausea and vomiting, enhance cancer patients’ appetites, and treat COVID-19 patients. There is little evidence of the impact of a dexamethasone treatment plan on the severity
Lina Souan +4 more
doaj +1 more source
Dexamethasone bovine pharmacokinetics [PDF]
European Journal of Drug Metabolism and Pharmacokinetics, 1991 Dexamethasone phosphate (DXM-PHO) is an ester which is quickly hydrolysed by the bovine and the dexamethasone (DXM) plasma half-life was 5.16 h. It has been demonstrated that 54 h after DXM-PHO injection, DXM concentrations were lower than 0.1 mg/ml.
Gaignage, Ph +6 more
openaire +2 more sources
Journal of Microbiology, Immunology and Infection, 2021 Objective: We aimed to analyze clinical outcomes from patients with severe COVID-19 pneumonia that received either baricitinib plus dexamethasone or dexamethasone monotherapy. Methodology: We performed a retrospective comparative study.
Eduardo Pérez-Alba +7 more
doaj +1 more source