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Dexmedetomidine in anaesthesia
Current Opinion in Anaesthesiology, 2005The development of dexmedetomidine, a potent and highly selective alpha2-adrenoceptor agonist, has created new interest in the use of alpha2-adrenoceptor agonists, and has led to its evaluation in various yet non-approved perioperative settings. The current review focuses on the usefulness of dexmedetomidine in anaesthesia practice.Recently acquired ...
Andrea, Paris, Peter H, Tonner
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Journal of the American Veterinary Medical Association, 2003
Abstract Objective—To determine sedative and cardiorespiratory effects of dexmedetomidine alone and in combination with butorphanol or ketamine in cats. Design—Randomized crossover study. Animals—6 healthy adult cats. Procedures—Cats were given dexmedetomidine alone (10 μg/kg [4.5 mg/lb], IM), a combination of ...
André L, Selmi +4 more
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Abstract Objective—To determine sedative and cardiorespiratory effects of dexmedetomidine alone and in combination with butorphanol or ketamine in cats. Design—Randomized crossover study. Animals—6 healthy adult cats. Procedures—Cats were given dexmedetomidine alone (10 μg/kg [4.5 mg/lb], IM), a combination of ...
André L, Selmi +4 more
openaire +2 more sources
Drugs of Today, 1999
Pharmacological manipulation of the sympathetic tone has led to the synthesis of novel compounds to control stress-induced hemodynamic disorders. The use of alpha(2)-adrenoceptor agonists is particularly interesting in this regard, since these agents decrease sympathetic activity by reducing norepinephrine release from nerve terminals.
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Pharmacological manipulation of the sympathetic tone has led to the synthesis of novel compounds to control stress-induced hemodynamic disorders. The use of alpha(2)-adrenoceptor agonists is particularly interesting in this regard, since these agents decrease sympathetic activity by reducing norepinephrine release from nerve terminals.
openaire +2 more sources
Survey of Anesthesiology, 1993
To evaluate the effects of dexmedetomidine, an alpha-2 agonist, as an intravenous sedative drug and the effects of atipamezole, an alpha-2 antagonist, on recovery.Randomized, double-blind study with three parallel groups. An open dose-finding study preceded it to optimize the atipamezole dose.Outpatient operating room at the gynecologic and obstetric ...
M, Aho +4 more
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To evaluate the effects of dexmedetomidine, an alpha-2 agonist, as an intravenous sedative drug and the effects of atipamezole, an alpha-2 antagonist, on recovery.Randomized, double-blind study with three parallel groups. An open dose-finding study preceded it to optimize the atipamezole dose.Outpatient operating room at the gynecologic and obstetric ...
M, Aho +4 more
openaire +2 more sources
Dexmedetomidine as an Adjuvant in Peripheral Nerve Block
Drug Design, Development and Therapy, 2023Zheping Chen, Chang Feng, Yanwu Jin
exaly
The immunomodulatory mechanism of dexmedetomidine
International Immunopharmacology, 2021Koichi Yuki
exaly