Results 281 to 290 of about 63,586 (320)
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Der Anaesthesist, 2013
Dexmedetomidine is a highly selective α2-receptor agonist with sedative, analgetic and anxiolytic effects. It is chemically related to clonidine and has been an authorized drug in Europe since September 2011. Dexmedetomidine enables a level of sedation in which mechanically ventilated patients may be woken by verbal stimulation (Richmond agitation ...
G. Gerresheim, U. Schwemmer
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Dexmedetomidine is a highly selective α2-receptor agonist with sedative, analgetic and anxiolytic effects. It is chemically related to clonidine and has been an authorized drug in Europe since September 2011. Dexmedetomidine enables a level of sedation in which mechanically ventilated patients may be woken by verbal stimulation (Richmond agitation ...
G. Gerresheim, U. Schwemmer
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Drugs, 2000
Dexmedetomidine is a potent alpha2-adrenoceptor agonist with 8 times higher affinity for the alpha2-adrenoceptor than clonidine. Dexmedetomidine has shown sedative, analgesic and anxiolytic effects after intravenous administration to healthy volunteers or postsurgical patients in the intensive care unit.
Karen L. Goa +2 more
openaire +3 more sources
Dexmedetomidine is a potent alpha2-adrenoceptor agonist with 8 times higher affinity for the alpha2-adrenoceptor than clonidine. Dexmedetomidine has shown sedative, analgesic and anxiolytic effects after intravenous administration to healthy volunteers or postsurgical patients in the intensive care unit.
Karen L. Goa +2 more
openaire +3 more sources
Current Opinion in Critical Care, 2001
Effective use of sedative-hypnotic and analgesic agents is an integral part of providing patient comfort and safety. Of the numerous drugs administered, benzodiazepines, propofol, and narcotics are the most popular. Even these proven, time-tested sedative-hypnotics and analgesics are not perfect, however, and modern intensive care demands a more ideal ...
D B, Coursin +2 more
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Effective use of sedative-hypnotic and analgesic agents is an integral part of providing patient comfort and safety. Of the numerous drugs administered, benzodiazepines, propofol, and narcotics are the most popular. Even these proven, time-tested sedative-hypnotics and analgesics are not perfect, however, and modern intensive care demands a more ideal ...
D B, Coursin +2 more
openaire +2 more sources
Journal of Veterinary Pharmacology and Therapeutics, 2012
The purpose of this study was to assess the clinical effects of dexmedetomidine, both alone and combined with pethidine or butorphanol, in cats. A prospective randomized blind study was performed. Thirty cats were randomly assigned to three groups of 10 animals: D: dexmedetomidine (20 μg/kg IM); DP: dexmedetomidine (10 μg/kg IM) and pethidine (2.5 mg ...
L. Gil +5 more
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The purpose of this study was to assess the clinical effects of dexmedetomidine, both alone and combined with pethidine or butorphanol, in cats. A prospective randomized blind study was performed. Thirty cats were randomly assigned to three groups of 10 animals: D: dexmedetomidine (20 μg/kg IM); DP: dexmedetomidine (10 μg/kg IM) and pethidine (2.5 mg ...
L. Gil +5 more
openaire +3 more sources
Regional anesthesia and pain medicine, 2021
Background Dexmedetomidine is an effective local anesthetic adjunct for peripheral nerve blocks. The intravenous route for administering dexmedetomidine has been suggested to be equally effective to the perineural route; but comparative evidence is ...
N. Hussain +6 more
semanticscholar +1 more source
Background Dexmedetomidine is an effective local anesthetic adjunct for peripheral nerve blocks. The intravenous route for administering dexmedetomidine has been suggested to be equally effective to the perineural route; but comparative evidence is ...
N. Hussain +6 more
semanticscholar +1 more source
Der Anaesthesist, 2012
Dexmedetomidine is a highly selective, potent α₂-adrenoceptor agonist which was approved in 2011 by the European Medicines Agency for sedation of patients in intensive care units (ICU). Dexmedetomidine exhibits sedative as well as analgesic and anxiolytic effects.
T.I. Saari, H. Ihmsen
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Dexmedetomidine is a highly selective, potent α₂-adrenoceptor agonist which was approved in 2011 by the European Medicines Agency for sedation of patients in intensive care units (ICU). Dexmedetomidine exhibits sedative as well as analgesic and anxiolytic effects.
T.I. Saari, H. Ihmsen
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Dexmedetomidine in anaesthesia
Current Opinion in Anaesthesiology, 2005The development of dexmedetomidine, a potent and highly selective alpha2-adrenoceptor agonist, has created new interest in the use of alpha2-adrenoceptor agonists, and has led to its evaluation in various yet non-approved perioperative settings. The current review focuses on the usefulness of dexmedetomidine in anaesthesia practice.Recently acquired ...
A. Paris, Peter H. Tonner
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Journal of the American Veterinary Medical Association, 2003
Abstract Objective—To determine sedative and cardiorespiratory effects of dexmedetomidine alone and in combination with butorphanol or ketamine in cats. Design—Randomized crossover study. Animals—6 healthy adult cats. Procedures—Cats were given dexmedetomidine alone (10 μg/kg [4.5 mg/lb], IM), a combination of ...
André Luis Selmi +4 more
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Abstract Objective—To determine sedative and cardiorespiratory effects of dexmedetomidine alone and in combination with butorphanol or ketamine in cats. Design—Randomized crossover study. Animals—6 healthy adult cats. Procedures—Cats were given dexmedetomidine alone (10 μg/kg [4.5 mg/lb], IM), a combination of ...
André Luis Selmi +4 more
openaire +2 more sources
Drugs of Today, 1999
Pharmacological manipulation of the sympathetic tone has led to the synthesis of novel compounds to control stress-induced hemodynamic disorders. The use of alpha(2)-adrenoceptor agonists is particularly interesting in this regard, since these agents decrease sympathetic activity by reducing norepinephrine release from nerve terminals.
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Pharmacological manipulation of the sympathetic tone has led to the synthesis of novel compounds to control stress-induced hemodynamic disorders. The use of alpha(2)-adrenoceptor agonists is particularly interesting in this regard, since these agents decrease sympathetic activity by reducing norepinephrine release from nerve terminals.
openaire +2 more sources
Survey of Anesthesiology, 1993
To evaluate the effects of dexmedetomidine, an alpha-2 agonist, as an intravenous sedative drug and the effects of atipamezole, an alpha-2 antagonist, on recovery.Randomized, double-blind study with three parallel groups. An open dose-finding study preceded it to optimize the atipamezole dose.Outpatient operating room at the gynecologic and obstetric ...
Antero Kallio +9 more
openaire +3 more sources
To evaluate the effects of dexmedetomidine, an alpha-2 agonist, as an intravenous sedative drug and the effects of atipamezole, an alpha-2 antagonist, on recovery.Randomized, double-blind study with three parallel groups. An open dose-finding study preceded it to optimize the atipamezole dose.Outpatient operating room at the gynecologic and obstetric ...
Antero Kallio +9 more
openaire +3 more sources