The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19
Frontiers in Medicine, 2022 There is a need for treatments to reduce coronavirus disease 2019 (COVID-19) mortality. Alpha-2 adrenergic receptor (α2 AR) agonists can dampen immune cell and inflammatory responses as well as improve oxygenation through physiologic respiratory ...
John L. Hamilton +5 more
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PharmaceuticalsAccidental poisonings by ingesting conjunctival fluid mixed with eye drops commonly involve alpha-2 adrenergic receptor agonists and tetrahydrozoline. These substances are recognized in commonly reported ingestions. Victims of all ages, otherwise in good
Ivan Šoša
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Amitraz poisoning mimicking organophosphate toxicity in a young woman: a clinically diagnosed case report from Western India [PDF]
International Journal of Emergency MedicineBackground Amitraz is a formamidine insecticide and acaricide widely used in veterinary and agricultural settings. Human poisoning with amitraz is uncommon but potentially serious, primarily due to its alpha-2 adrenergic agonist activity, monoamine ...
Setu Patel, Bharti Chaudhari, Jay Nagda
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Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis [PDF]
Pharmacology & Therapeutics, 2009 Endogenous, descending noradrenergic fibers impose analgesic control over spinal afferent circuitry mediating the rostrad transmission of pain signals. These fibers target alpha 2 adrenergic receptors (alpha(2)ARs) on both primary afferent terminals and secondary neurons, and their activation mediates substantial inhibitory control over this ...
Carolyn A Fairbanks +2 more
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Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. [PDF]
Molecular Biology of the Cell, 1990 To test the hypothesis that agents activating receptors negatively coupled to adenylyl cyclase (AC) can stimulate cell proliferation, we have expressed a human alpha 2-adrenergic receptor (alpha 2-C10) in CCL39 cells and studied the effects of alpha 2-agonists on reinitiation of DNA synthesis in quiescent cells.
Klaus Seuwen +2 more
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Health Technology AssessmentBackground Optimising comfort and ability to communicate for mechanically ventilated intensive care unit patients is a priority for clinicians, intensive care unit patients and their relatives. Current usual care is propofol-based sedation plus an opioid
Timothy S Walsh +6 more
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Bali Journal of Anesthesiology, 2021 Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. If the management of acute postoperative pain is not done properly, it can lead to the complication such as chronic pain.
Dewa Ayu Nyoman Isma Pratiwi +2 more
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Spinal anesthesia for elective ceasarean section: use of different doses of hyperbaric bupivacaine associated with morphine and clonidine [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To comparatively study the efficacy and maternal and fetal side-effects of two doses of bupivacaine associated with morphine and clonidine, administered by the subarachnoid route for cesarean section.
Angélica de Fátima de Assunção Braga +4 more
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Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]
PLoS ONE, 2010 RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon +4 more
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An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. [PDF]
PLoS ONE, 2017 Alpha-1 adrenergic receptors mediate adaptive effects in the heart and cardiac myocytes, and a myocyte survival pathway involving the alpha-1A receptor subtype and ERK activation exists in vitro. However, data in vivo are limited.
Megan D Montgomery +5 more
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