The Role of BK Potassium Channels in Analgesia Produced by Alpha-2 Adrenergic Receptors [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016 BACKGROUND AND OBJECTIVE: Millions of people suffer from pain worldwide, and annually, great economic costs are imposed on societies for pain relief. Analgesics such as alpha-2 adrenergic receptor agonists, which have low risk of complications, can be ...
E Hooshmand +2 more
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Amitraz poisoning mimicking organophosphate toxicity in a young woman: a clinically diagnosed case report from Western India [PDF]
International Journal of Emergency MedicineBackground Amitraz is a formamidine insecticide and acaricide widely used in veterinary and agricultural settings. Human poisoning with amitraz is uncommon but potentially serious, primarily due to its alpha-2 adrenergic agonist activity, monoamine ...
Setu Patel, Bharti Chaudhari, Jay Nagda
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The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19
Frontiers in Medicine, 2022 There is a need for treatments to reduce coronavirus disease 2019 (COVID-19) mortality. Alpha-2 adrenergic receptor (α2 AR) agonists can dampen immune cell and inflammatory responses as well as improve oxygenation through physiologic respiratory ...
John L. Hamilton +5 more
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Ex vivo and in silico evaluations of (E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid as a β3-adrenoreceptor agonist exerting anti-obesity, anti-inflammatory and hepatoprotective effects on Zucker rats. [PDF]
PLoS ONEObesity increases oxidative stress and inflammation and thereby promotes liver damage and metabolic disorders, such as type 2 diabetes. Although exist anti-obesity treatments with employing anorexic drugs, antioxidants, and β3-adrenergic receptor (β3-ADR)
Laura Cristina Cabrera-Pérez +6 more
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Bali Journal of Anesthesiology, 2021 Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. If the management of acute postoperative pain is not done properly, it can lead to the complication such as chronic pain.
Dewa Ayu Nyoman Isma Pratiwi +2 more
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Spinal anesthesia for elective ceasarean section: use of different doses of hyperbaric bupivacaine associated with morphine and clonidine [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To comparatively study the efficacy and maternal and fetal side-effects of two doses of bupivacaine associated with morphine and clonidine, administered by the subarachnoid route for cesarean section.
Angélica de Fátima de Assunção Braga +4 more
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Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]
PLoS ONE, 2010 RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon +4 more
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An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. [PDF]
PLoS ONE, 2017 Alpha-1 adrenergic receptors mediate adaptive effects in the heart and cardiac myocytes, and a myocyte survival pathway involving the alpha-1A receptor subtype and ERK activation exists in vitro. However, data in vivo are limited.
Megan D Montgomery +5 more
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Alpha-2 Adrenergic Receptor Agonists: A Review of Current Clinical Applications [PDF]
Anesthesia Progress, 2015 Abstract The α-2 adrenergic receptor agonists have been used for decades to treat common medical conditions such as hypertension; attention-deficit/hyperactivity disorder; various pain and panic disorders; symptoms of opioid, benzodiazepine, and alcohol withdrawal; and cigarette craving.1 However, in more recent years, these drugs have been ...
Joseph A, Giovannitti +2 more
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Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking [PDF]
Neuropsychopharmacology, 2000 The alpha-2 adrenergic receptor agonists, clonidine, lofexidine and guanabenz, blocked stress- but not cocaine-induced reinstatement of cocaine seeking at doses that suppressed footshock-induced release of noradrenaline in prefrontal cortex and amygdala.
Erb, Suzanne +5 more
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