Results 31 to 40 of about 20,695 (270)

Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]

, 2007
Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core   +1 more source

Effect of intraoperative Dexmedetomidine infusion on Sevoflurane requirement and blood glucose levels during entropy-guided general anesthesia

Journal of Anaesthesiology Clinical Pharmacology, 2014
Background: Dexmedetomidine has been shown to blunt the stress response to surgery. Hence a study was designed to evaluate the effect of intravenous (IV) Dexmedetomidine infusion during general anesthesia for abdominal surgeries on blood glucose levels ...
S S Harsoor, D Devika Rani, S Lathashree, S S Nethra, K Sudheesh   +4 more
doaj   +1 more source

Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord

Frontiers in Neural Circuits, 2010
Although it is known that noradrenaline powerfully controls spinal motor networks, few data are available regarding the noradrenergic modulation of intrinsic and synaptic properties of neurons in motor networks.
Maylis Tartas, Maylis Tartas, France Morin, Grégory Barrière, Michel Goillandeau, Jean-Claude Lacaille, Jean-René Cazalets, Sandrine S Bertrand   +7 more
doaj   +1 more source

An International Survey of Health Care Services Available to Patients With Tourette Syndrome

Frontiers in Psychiatry, 2021
Objective: Tourette syndrome (TS) is a neuropsychiatric disorder that is highly associated with several comorbidities. Given the complex and multifaceted nature of TS, the condition is managed by a wide variety of practitioners in different disciplines ...
Tracy Bhikram, Rana Elmaghraby, Rana Elmaghraby, Elia Abi-Jaoude, Elia Abi-Jaoude, Paul Sandor, Paul Sandor   +6 more
doaj   +1 more source

Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships

, 2008
Potent and selective histamine H2 receptor (H2R) agonists are valuable pharmacological tools and might be of therapeutic value as drugs, for example in the treatment of severe congestive heart failure.
Kraus, Anja
core   +1 more source

Brimonidine tartrate effect on retinal spreading depression depends on Müller cells

Revista Brasileira de Oftalmologia, 2014
Objective: Demonstrate the Brimonidine effect over Retinal Spreading Depression (SD). Brimonidine is an alpha-2–adrenergic receptor agonist, used in the management of glaucoma. Alpha2-agonists have been shown to be neuroprotective in various experimental
Vinícius Vanzan Pimentel de Oliveira, Marcio Penha Morterá Rodrigues, Adroaldo de Alencar, Sebastião Cronemberger, Nassim Calixto, Adalmir Morterá Dantas   +5 more
doaj   +1 more source

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]

, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Jackson, Edwin K., Blessing, CP, Tammy Liu, Liu, Tammy, Liu, T, Christopher P Blessing, Jackson Edwin K., Liu Tammy, Gul, R, Pulakat, Lakshmi, Pulakat, L, Murat Bastepe, Blessing, Christopher P., Edwin K Jackson, Catherine E Erickson, Rukhsana Gul, Bastepe Murat, Lakshmi Pulakat, Andresen Bradley T., Nguyen, J, Pulakat Lakshmi, Gul, Rukhsana, Andresen, Bradley T., Erickson, CE, Blessing Christopher P., Holowka, David, Nguyen Jenny, Bastepe, Murat, Jackson, EK, Andresen, BT, Gul Rukhsana, Jenny Nguyen, Erickson Catherine E., Bastepe, M, Erickson, Catherine E., Nguyen, Jenny, Bradley T Andresen   +36 more
core   +1 more source

Spinal Tolerance and Dependence: Some Observations on the Role of Spinal N-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses

Pain Research and Management, 2000
The continuous delivery of opiates can lead to a reduction in analgesic effects. In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component.
Tony L Yaksh, Xiao-Ying Hua
doaj   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Over-the-Counter Ocular Decongestants in the United States – Mechanisms of Action and Clinical Utility for Management of Ocular Redness

Clinical Optometry, 2020
Lester O Hosten,1 Christopher Snyder2 1Clinical and Medical Affairs, Bausch + Lomb, Bridgewater, NJ, USA; 2Regional Director Medical Science, Bausch + Lomb, Birmingham, AL, USACorrespondence: Lester O HostenClinical and Medical Affairs, Bausch + Lomb ...
Hosten LO, Snyder C
doaj