Results 31 to 40 of about 21,005 (156)

α-1-Adrenergic Receptor Agonist Activity of Clinical α-Adrenergic Receptor Agonists Interferes with α-2-Mediated Analgesia [PDF]

Anesthesiology, 2009
Background The use of alpha-2 adrenergic agonists for analgesia is limited due to a narrow therapeutic window. Definition of the role of alpha receptor subtypes in alpha agonist mediated analgesia may identify strategies to separate the analgesic from sedative and cardiovascular effects ...
Daniel W, Gil, Cynthia V, Cheevers, Karen M, Kedzie, Cynthia A, Manlapaz, Sandhya, Rao, Elaine, Tang, John E, Donello   +6 more
openaire   +2 more sources

Effect of intraoperative Dexmedetomidine infusion on Sevoflurane requirement and blood glucose levels during entropy-guided general anesthesia

Journal of Anaesthesiology Clinical Pharmacology, 2014
Background: Dexmedetomidine has been shown to blunt the stress response to surgery. Hence a study was designed to evaluate the effect of intravenous (IV) Dexmedetomidine infusion during general anesthesia for abdominal surgeries on blood glucose levels ...
S S Harsoor, D Devika Rani, S Lathashree, S S Nethra, K Sudheesh   +4 more
doaj   +1 more source

Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience

International Journal of Basic & Clinical Pharmacology, 2018
The alpha-2 adrenergic receptor (α-2 AR) agonists have a long history of use in treating different clinical conditions, such as hypertension, psychiatric entities (e.g., attention-deficit hyperactivity disorder), chronic pain, panic disorders, and, lately, for treating opioid withdrawal syndrome.
Jabril B. Eldufani, Nyruz R. Elahmer, Alireza Nekoui, Gilbert A. Blaise   +3 more
openaire   +2 more sources

Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord

Frontiers in Neural Circuits, 2010
Although it is known that noradrenaline powerfully controls spinal motor networks, few data are available regarding the noradrenergic modulation of intrinsic and synaptic properties of neurons in motor networks.
Maylis Tartas, Maylis Tartas, France Morin, Grégory Barrière, Michel Goillandeau, Jean-Claude Lacaille, Jean-René Cazalets, Sandrine S Bertrand   +7 more
doaj   +1 more source

Brimonidine tartrate effect on retinal spreading depression depends on Müller cells

Revista Brasileira de Oftalmologia, 2014
Objective: Demonstrate the Brimonidine effect over Retinal Spreading Depression (SD). Brimonidine is an alpha-2–adrenergic receptor agonist, used in the management of glaucoma. Alpha2-agonists have been shown to be neuroprotective in various experimental
Vinícius Vanzan Pimentel de Oliveira, Marcio Penha Morterá Rodrigues, Adroaldo de Alencar, Sebastião Cronemberger, Nassim Calixto, Adalmir Morterá Dantas   +5 more
doaj   +1 more source

An International Survey of Health Care Services Available to Patients With Tourette Syndrome

Frontiers in Psychiatry, 2021
Objective: Tourette syndrome (TS) is a neuropsychiatric disorder that is highly associated with several comorbidities. Given the complex and multifaceted nature of TS, the condition is managed by a wide variety of practitioners in different disciplines ...
Tracy Bhikram, Rana Elmaghraby, Rana Elmaghraby, Elia Abi-Jaoude, Elia Abi-Jaoude, Paul Sandor, Paul Sandor   +6 more
doaj   +1 more source

Spinal Tolerance and Dependence: Some Observations on the Role of Spinal N-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses

Pain Research and Management, 2000
The continuous delivery of opiates can lead to a reduction in analgesic effects. In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component.
Tony L Yaksh, Xiao-Ying Hua
doaj   +1 more source

Over-the-Counter Ocular Decongestants in the United States – Mechanisms of Action and Clinical Utility for Management of Ocular Redness

Clinical Optometry, 2020
Lester O Hosten,1 Christopher Snyder2 1Clinical and Medical Affairs, Bausch + Lomb, Bridgewater, NJ, USA; 2Regional Director Medical Science, Bausch + Lomb, Birmingham, AL, USACorrespondence: Lester O HostenClinical and Medical Affairs, Bausch + Lomb ...
Hosten LO, Snyder C
doaj  

Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. [PDF]

Cell Regulation, 1990
To test the hypothesis that agents activating receptors negatively coupled to adenylyl cyclase (AC) can stimulate cell proliferation, we have expressed a human alpha 2-adrenergic receptor (alpha 2-C10) in CCL39 cells and studied the effects of alpha 2-agonists on reinitiation of DNA synthesis in quiescent cells.
K, Seuwen, I, Magnaldo, B K, Kobilka, M G, Caron, J W, Regan, R J, Lefkowitz, J, Pouysségur   +6 more
openaire   +2 more sources

Role of cyclic AMP and cyclic GMP as modulators of platelet cytosolic calcium

Journal of Clinical and Preventive Cardiology, 2016
Studies from our laboratory at the University of Minnesota as well as that of others have demonstrated that agonist-mediated receptor stimulation leads to the activation of phospholipase C and formation of second messengers, diacyl glycerol and inositol ...
Gundu H.R. Rao
doaj   +1 more source