Results 21 to 30 of about 20,695 (270)

Evaluation of Dexmedetomidine as an Adjuvant to Intrathecal Bupivacaine in Infraumbilical Surgeries [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Various adjuvants like morphine, buprenorphine and fentanyl, clonidine, ketamine are being used in anaesthetic practice since long for improvement of peri-operative analgesia following spinal anaesthesia. Such adjuvants have been helpful
Sisinti Sanjeeb Patro, Hemant Deshmukh, Yerramalli Roja Ramani, Gitanjali Das   +3 more
doaj   +1 more source

The interaction of tiotropium with long lasting β2-agonists on lung cell function [PDF]

, 2013
The major question addressed in this thesis was to find the mechanism(s) by which muscarinic receptors interact with β2-adrenergic receptors in human airway fibroblasts.
Costa, Luigi
core   +1 more source

Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia

BMC Anesthesiology, 2021
Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the ...
Chen Bin, Wang Xiaohui, Shi Mengrou, Li Xin, Zhang Ting, Gao Ping   +5 more
doaj   +1 more source

Inhibition of sequestration of human B-2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells [PDF]

, 2004
Depending on their interaction with intracellular proteins, G proteincoupled receptors (GPCR) often display different affinities for agonists at 37degreesC. Determining the affinity at that temperature is often difficult in intact cells as most GPCRs are
Faussner, Alexander, Jochum, Marianne, Schuessler, Steffen, Seidl, Cornelia   +3 more
core   +1 more source

Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial

BMJ Open, 2022
Introduction Postoperative delirium is common in older cardiac surgery patients and associated with negative short-term and long-term outcomes. The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for ...
Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba   +18 more
doaj   +1 more source

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1987
Desensitization of the beta-adrenergic receptor, a receptor which is coupled to the stimulation of adenylate cyclase, may be regulated via phosphorylation by a unique protein kinase. This recently discovered enzyme, known as the beta-adrenergic receptor kinase, only phosphorylates the agonist-occupied form of the beta-adrenergic receptor.
BENOVIC J. L, REGAN J. W, MATSUI H, MAYOR F. JR, LEEB LUNDBERG F. L. M, CARON M. G, LEFKOWITZ R. J., COTECCHIA, Susanna   +7 more
openaire   +2 more sources

α-1-Adrenergic Receptor Agonist Activity of Clinical α-Adrenergic Receptor Agonists Interferes with α-2-Mediated Analgesia [PDF]

Anesthesiology, 2009
Background The use of alpha-2 adrenergic agonists for analgesia is limited due to a narrow therapeutic window. Definition of the role of alpha receptor subtypes in alpha agonist mediated analgesia may identify strategies to separate the analgesic from sedative and cardiovascular effects ...
Daniel W, Gil, Cynthia V, Cheevers, Karen M, Kedzie, Cynthia A, Manlapaz, Sandhya, Rao, Elaine, Tang, John E, Donello   +6 more
openaire   +2 more sources

Evaluation of Nebulised Dexmedetomidine in Blunting Haemodynamic Response to Laryngoscopy and Intubation in Adults Undergoing General Anaesthesia for Laparoscopic Surgeries: A Randomised Control Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Laryngoscopy and endotracheal intubation can trigger sympathetic stimulation, potentially leading to cardiovascular or cerebrovascular complications in high-risk patients.
Et Muhammed Jaseel, Shweta Sedani, Dipakkumar Hiralal Ruparel, Ramesh Sugandh   +3 more
doaj   +1 more source

Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. [PDF]

, 2008
Antihypertensive drugs are believed to lower blood pressure in pre-eclampsia by direct or central vasodilatory mechanisms. However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension ...
Muttukrishna Shanthi, Muttukrishna, S, Khalil Asma, Khalil, A, Jauniaux, E, Harrington, K, Jauniaux Eric, Kevin Harrington, Harrington Kevin, Shanthi Muttukrishna, Asma Khalil, Eric Jauniaux   +11 more
core   +1 more source

Pharmacologically Induced Ex Copula Ejaculation in Horses and Donkeys

Frontiers in Veterinary Science, 2021
Pharmacologically induced ex copula ejaculation is a method used for collection of semen when the traditional methods of semen collection are not feasible.
Afroza Khanam, Ayman A. Swelum, Ayman A. Swelum, Firdous A. Khan   +3 more
doaj   +1 more source