Results 21 to 30 of about 21,005 (156)

Adjuvant dexmedetomidine in treatment of alcohol withdrawal delirium: Case series

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Alcohol withdrawal delirium is a medical emergency with mortality rates of 20–50% without treatment. Benzodiazepines (BZDs) (gamma-aminobutyric acid receptor agonists) are the mainstay of treatment.
Amit Chail, Madhubrata Ray, Ranveer Singh, Mayank Dhiman   +3 more
doaj   +1 more source

Evaluation of Dexmedetomidine as an Adjuvant to Intrathecal Bupivacaine in Infraumbilical Surgeries [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Various adjuvants like morphine, buprenorphine and fentanyl, clonidine, ketamine are being used in anaesthetic practice since long for improvement of peri-operative analgesia following spinal anaesthesia. Such adjuvants have been helpful
Sisinti Sanjeeb Patro, Hemant Deshmukh, Yerramalli Roja Ramani, Gitanjali Das   +3 more
doaj   +1 more source

Interactions of Agonists with Platelet α₂-Adrenergic Receptors [PDF]

Endocrinology, 1982
Epinephrine induces human platelet aggregation by interacting with alpha-adrenergic receptors. These sites were demonstrated by radioligand-binding techniques using the new antagonist ligand, [3H]yohimbine. The sites labeled by [3H]yohimbine had the specificity of alpha 2-receptors with the affinity of yohimbine much greater than prazosin.
B B, Hoffman, T, Michel, T B, Brenneman, R J, Lefkowitz   +3 more
openaire   +2 more sources

Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia

BMC Anesthesiology, 2021
Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the ...
Chen Bin, Wang Xiaohui, Shi Mengrou, Li Xin, Zhang Ting, Gao Ping   +5 more
doaj   +1 more source

Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking [PDF]

Neuropsychopharmacology, 2000
The alpha-2 adrenergic receptor agonists, clonidine, lofexidine and guanabenz, blocked stress- but not cocaine-induced reinstatement of cocaine seeking at doses that suppressed footshock-induced release of noradrenaline in prefrontal cortex and amygdala.
Erb, Suzanne, HITCHCOTT, PAUL KENNETH, Rajabi, Heshmat, Mueller, Devin, Shaham, Yavin, Stewart, Jane   +5 more
openaire   +3 more sources

Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial

BMJ Open, 2022
Introduction Postoperative delirium is common in older cardiac surgery patients and associated with negative short-term and long-term outcomes. The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for ...
Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba   +18 more
doaj   +1 more source

Comparison of Intravenous Magnesium Sulphate and Dexmedetomidine for Attenuation of Cardiovascular Stress Response during Laryngoscopy and Endotracheal Intubation: A Double-blinded Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Laryngoscopy and intubation provoke sympathetic tachycardia and hypertension. These transient changes may precipitate adverse effects in patients with undiagnosed co-morbidities.
Praneetha Vijayan, Thounaojam Dinesh Singh, Kajal Momin   +2 more
doaj   +1 more source

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1987
Desensitization of the beta-adrenergic receptor, a receptor which is coupled to the stimulation of adenylate cyclase, may be regulated via phosphorylation by a unique protein kinase. This recently discovered enzyme, known as the beta-adrenergic receptor kinase, only phosphorylates the agonist-occupied form of the beta-adrenergic receptor.
BENOVIC J. L, REGAN J. W, MATSUI H, MAYOR F. JR, LEEB LUNDBERG F. L. M, CARON M. G, LEFKOWITZ R. J., COTECCHIA, Susanna   +7 more
openaire   +2 more sources

Evaluation of Nebulised Dexmedetomidine in Blunting Haemodynamic Response to Laryngoscopy and Intubation in Adults Undergoing General Anaesthesia for Laparoscopic Surgeries: A Randomised Control Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Laryngoscopy and endotracheal intubation can trigger sympathetic stimulation, potentially leading to cardiovascular or cerebrovascular complications in high-risk patients.
Et Muhammed Jaseel, Shweta Sedani, Dipakkumar Hiralal Ruparel, Ramesh Sugandh   +3 more
doaj   +1 more source

Pharmacologically Induced Ex Copula Ejaculation in Horses and Donkeys

Frontiers in Veterinary Science, 2021
Pharmacologically induced ex copula ejaculation is a method used for collection of semen when the traditional methods of semen collection are not feasible.
Afroza Khanam, Ayman A. Swelum, Ayman A. Swelum, Firdous A. Khan   +3 more
doaj   +1 more source