Results 1 to 10 of about 32,465 (232)

Impact of perioperative clonidine on postoperative respiratory adverse events in children: a post-hoc observational analysis of prospectively collected datasets [PDF]

Brazilian Journal of Anesthesiology
Background: Clonidine, an alpha-2-agonist, has several applications in pediatric anesthesia. Sympathetic nervous system-mediated pathways contribute to airway reactivity, suggesting that clonidine could mitigate respiratory adverse events similarly to ...
David Sommerfield, Bojana Stepanovic, Daisy Evans, Andy Jeon, Anne Louise de Barros Garioud, Aine Sommerfield, Neil Hauser, R. Nazim Khan, Britta S. von Ungern-Sternberg   +8 more
doaj   +2 more sources

Safety and tolerability study of clonidine for sedation in mechanically ventilated adult patients [PDF]

Journal of Anesthesia, Analgesia and Critical Care
Background Clonidine is used as an adjunct sedative in mechanically ventilated ICU patients, but prospective data on the safety and tolerability of higher intravenous doses remain limited.
Huub L. A. van den Oever, Marieke Zeeman, Eline Klaas, Polina Nassikovker, Carmen Bles, Arthur R. de Meijer, Arriette Kruisdijk-Gerritsen, Maurits E. Arbouw   +7 more
doaj   +2 more sources

Clonidine protects rat hippocampal and cortical neurons from oxygen-glucose deprivation and reoxygenation-induced injury through HCN Channels [PDF]

Scientific Reports
Our prior research demonstrated that the neuroprotective effects of clonidine can be reversed by yohimbine, an α2-adrenergic receptor antagonist. Additionally, clonidine has been shown to alleviate anxiety-like behavior in rats after bilateral common ...
Ke Wang, Wen-Jing Yan, Gang Li, Jue Liu, Yue Chen, Zi-Cheng Li, Zhi He   +6 more
doaj   +2 more sources

Electrophysiological evidence about sexual dimorphism in the clonidine-induced inhibition of trigeminal wide dynamic range cell activity [PDF]

The Journal of Headache and Pain
Background The trigeminal system plays a key role in headaches pathophysiology. In this regard, nociceptive experiments in male rodents have shown that at the trigeminal level, clonidine induces antinociception through α2A- but not α2B/2C-adrenoceptors ...
Gustavo López-Córdoba, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Abimael González-Hernández   +3 more
doaj   +2 more sources

Effects of α2-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum.

PLoS ONE, 2022
The sympathetic nervous system is highly involved in the regulation of gastrointestinal functions such as luminal alkalinisation and fluid absorption. However, the exact mechanisms are not clear.
Olof Nylander, Markus Sjöblom, John Sedin, David Dahlgren   +3 more
doaj   +1 more source

Clonidine Use for the Treatment of Nightmares in Posttraumatic Stress Disorder

Case Reports in Psychiatry, 2022
Introduction. While clonidine is used clinically for the treatment of nightmares in posttraumatic stress disorder (PTSD), few case reports demonstrating this indication exist, and there have been few studies investigating clonidine’s mechanism of action ...
Jill S. Bange, Kelly E. Melvin
doaj   +1 more source

The effect of ritonavir on the pharmacokinetics of clonidine

Pakistan Journal of Pharmaceutical Sciences, 2023
This project aims to explore the repercussions of ritonavir on both the drug kinetics of clonidine in rats and clonidine metabolism in liver microsomes.
in vivo, in vitro Peng Wang, Xiaoxia Hu Jinhua, Zhejiang, China.   +4 more
doaj   +1 more source

Stability of clonidine hydrochloride in an oral powder form compounded for pediatric patients in Japan

Journal of Pharmaceutical Health Care and Sciences, 2021
Background Clonidine hydrochloride is used to treat sedative agent withdrawals, malignant hypertension, and anesthesia complications. Clonidine is also prescribed off-label to pediatric patients at a dose of 1 μg/kg.
Jumpei Saito, Takehisa Hanawa, Takahiro Matsumoto, Nozomi Yoshikawa, Tsutomu Harada, Kana Iwahashi, Hidefumi Nakamura, Akimasa Yamatani   +7 more
doaj   +1 more source

A randomized study of comparison between Intravenous infusion of 0.5 mcg/kg of clonidine and 1 mcg/kg of clonidine on hemodynamic stress response to pnuemo peritoneum and intubation response during laparoscopic surgeries in a tertiary care hospital in a sub urban population

Asian Journal of Medical Sciences, 2022
Background: The laparoscopic surgical procedure has made remarkable changes in the surgical field. Conditions, such as pneumoperitoneum, has an impact on several homeostatic systems.
Sindhuja Somasundaram , Selvakumaran Pannirselvam   +1 more
doaj   +1 more source

Medication Safety in Intravenous Therapy: A Compatibility Study of Clonidine with Drugs Frequently Used in Intensive Care

Pharmaceutics, 2020
The intravenous pharmacotherapy of critically ill patients is extremely challenging due to the high number of drugs administered. We therefore evaluated the physicochemical compatibility of combinations of clonidine with drugs frequently used in an ...
Anna Katharina Koller, Sabine Krebs, Frank Dörje   +2 more
doaj   +1 more source