Clonidine protects rat hippocampal and cortical neurons from oxygen-glucose deprivation and reoxygenation-induced injury through HCN Channels [PDF]
Scientific ReportsOur prior research demonstrated that the neuroprotective effects of clonidine can be reversed by yohimbine, an α2-adrenergic receptor antagonist. Additionally, clonidine has been shown to alleviate anxiety-like behavior in rats after bilateral common ...
Ke Wang +6 more
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Electrophysiological evidence about sexual dimorphism in the clonidine-induced inhibition of trigeminal wide dynamic range cell activity [PDF]
The Journal of Headache and PainBackground The trigeminal system plays a key role in headaches pathophysiology. In this regard, nociceptive experiments in male rodents have shown that at the trigeminal level, clonidine induces antinociception through α2A- but not α2B/2C-adrenoceptors ...
Gustavo López-Córdoba +3 more
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Clonidine Use for the Treatment of Nightmares in Posttraumatic Stress Disorder
Case Reports in Psychiatry, 2022 Introduction. While clonidine is used clinically for the treatment of nightmares in posttraumatic stress disorder (PTSD), few case reports demonstrating this indication exist, and there have been few studies investigating clonidine’s mechanism of action ...
Jill S. Bange, Kelly E. Melvin
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Effects of α2-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum.
PLoS ONE, 2022 The sympathetic nervous system is highly involved in the regulation of gastrointestinal functions such as luminal alkalinisation and fluid absorption. However, the exact mechanisms are not clear.
Olof Nylander +3 more
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Journal of Pharmaceutical Health Care and Sciences, 2021 Background Clonidine hydrochloride is used to treat sedative agent withdrawals, malignant hypertension, and anesthesia complications. Clonidine is also prescribed off-label to pediatric patients at a dose of 1 μg/kg.
Jumpei Saito +7 more
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Asian Journal of Medical Sciences, 2022 Background: The laparoscopic surgical procedure has made remarkable changes in the surgical field. Conditions, such as pneumoperitoneum, has an impact on several homeostatic systems.
Sindhuja Somasundaram +1 more
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Pharmaceutics, 2020 The intravenous pharmacotherapy of critically ill patients is extremely challenging due to the high number of drugs administered. We therefore evaluated the physicochemical compatibility of combinations of clonidine with drugs frequently used in an ...
Anna Katharina Koller +2 more
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Brain Sciences, 2023 Clonidine, an alpha-2 adrenergic agonist, has been proposed as an antimanic agent that acts by reducing noradrenergic transmission. We conducted a systematic review to examine the efficacy and safety of clonidine for acute mania/hypomania.
Prakamya Singal +5 more
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Efficacy of low dose intravenous dexmedetomidine versus clonidine in treatment of shivering during caesarean section under spinal anaesthesia: a double blind randomized controlled trial [PDF]
New Indian Journal of OBGYN, 2023 Objectives: Dexmedetomidine and clonidine have been used to prevent and treat shivering after spinal anaesthesia. A double blind randomized controlled trial was conducted to compare the efficacy and safety of low dose intravenous dexmedetomidine and ...
Karamchand Basumatary +5 more
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Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in oocytes [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundClonidine has been shown to be a potent neuroprotectant by acting at α2 receptors on glutamatergic neurons to inhibit the release of glutamate.
Jae Hee Woo +3 more
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