Results 31 to 40 of about 22,511 (192)

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Gabapentin versus Clonidine Premedication for Haemodynamic Stability and Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomised Double-blind Control Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Laparoscopic cholecystectomy is associated with haemodynamic stress responses and significant postoperative pain due to CO2 insufflation and peritoneal irritation.
Mahima Manchanda, Seema Tikku Sharma, Kanika Sachdeva, Gurpreet Kaur Atwal, Neha Mehra   +4 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Clonidine Overdose as an Unusual Cause of Heart Failure

Journal of Investigative Medicine High Impact Case Reports, 2022
Clonidine is used as an antihypertensive medication due to its effect on decreasing peripheral vascular resistance and therefore lowering blood pressure.
Jagdeep Bhullar PharmD, Arti Patel MS4, Jaagruthi Chitithoti DO, Frederick Venter MD, Theingi Win MD, Fowrooz Joolhar MD   +5 more
doaj   +1 more source

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

Effect of Oral Clonidine Premedication on Induction Dose of Propofol and Perioperative Haemodynamic Parameters in Patients Undergoing Laparoscopic Cholecystectomy: A Double-blinded Randomised Controlled Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Clonidine increases the effects of anaesthesia and possesses antihypertensive qualities. During laparoscopic cholecystectomy, pneumoperitoneum is created by inflating Carbon Dioxide (CO2), which stimulates autonomic pathways, resulting in ...
Dheer Singh, Rakesh Bahadur Singh, Matendra Singh Yadav, Amit Kumar Singh, Purva Kumrawat, Chandra Bhushan Yadav   +5 more
doaj   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

The effect of clonidine as preanesthetic medication in children

Iranian South Medical Journal, 2003
Separation of children from their parents at the time of transfer to operating room commonly cause severe anxiety which can induce undesired physiologic and psychologic Sequalea. For the purpose of sedation different pharmacologic and non pharmacological
Behzad Maghsoodi, Seyed Ahmad Rakeie, Seyed Ziaoldin Behin Aeen   +2 more
doaj  

The effect of oral clonidine premedication on blood loss in primary total hip arthroplasty: A randomized placebo-controlled trial [PDF]

Archives of Trauma Research
Background: Substantial blood loss is a major concern in primary total hip arthroplasty and thus various blood conservation techniques are used to reduce blood loss in this surgery.
Shideh Dabir, Reza Zandi, Mastaneh Dahi Taleghani, Mohammadreza Moshari, Rahil Farahani, Maryam Vosoughian, Soudeh Tabashi   +6 more
doaj   +1 more source

Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14–40 Hz) and gamma (40–80 Hz) frequency bands ...
Marcel Heers, Jawata Afnan, Christoph Braun, Christophe Grova, Dirk‐Matthias Altenmüller, Bernhard J. Steinhoff, Matthias Dümpelmann, Theo Demerath, Horst Urbach, Silke Ethofer, Markus Siegel, Andreas Schulze‐Bonhage, Holger Lerche, Yiwen Li Hegner   +13 more
wiley   +1 more source