Results 31 to 40 of about 22,559 (187)

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Sciatic lateral popliteal block with clonidine alone or clonidine plus 0.2% ropivacaine: effect on the intra-and postoperative analgesia for lower extremity surgery in children: a randomized prospective controlled study

BMC Anesthesiology, 2012
Background The effect of adding clonidine to local anesthetics for nerve or plexus blocks remains unclear. Most of the studies in adults have demonstrated the positive effects of clonidine on intra- and postoperative analgesia when used as an adjunctive ...
Petroheilou Kalliopi, Livanios Stavros, Zavras Nikolaos, Hager John, Fassoulaki Argyro   +4 more
doaj   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, EarlyView.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Gabapentin versus Clonidine Premedication for Haemodynamic Stability and Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomised Double-blind Control Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Laparoscopic cholecystectomy is associated with haemodynamic stress responses and significant postoperative pain due to CO2 insufflation and peritoneal irritation.
Mahima Manchanda, Seema Tikku Sharma, Kanika Sachdeva, Gurpreet Kaur Atwal, Neha Mehra   +4 more
doaj   +1 more source

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy

Epileptic Disorders, EarlyView.
Abstract Background and Objectives KBG syndrome is a rare autosomal developmental disorder caused by pathogenic variants of the ANKRD11 gene. This scoping review aimed to explore all current literature data regarding clinical and electroencephalographic features of patients with KBG syndrome and epilepsy. Materials and Methods We conducted a literature
Stefania Kalampokini, Evripidis Pityrigkas, Zoi Kallia, Georgia Pepe, Antonis Frontistis, Dimitrios Profer, Vasilios Kimiskidis   +6 more
wiley   +1 more source

Menopausal hormone therapy and comprehensive postmenopausal care in gynecologic cancer survivors: A position paper from the FIGO Committee on Women at Menopausal Age

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Recent advances in cancer screening, diagnosis, and treatment have greatly improved survival rates among women with gynecologic cancers. More survivors now live long enough to experience treatment‐related menopause. Vasomotor symptoms, genitourinary syndrome of menopause, sexual dysfunction, sleep issues, and long‐term risks from estrogen ...
Agnaldo Lopes da Silva‐Filho, Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea R. Genazzani, Diana Ramos, Elizabete Argale, Enrique Herrera, Martha Hickey   +8 more
wiley   +1 more source

The effect of clonidine as preanesthetic medication in children

Iranian South Medical Journal, 2003
Separation of children from their parents at the time of transfer to operating room commonly cause severe anxiety which can induce undesired physiologic and psychologic Sequalea. For the purpose of sedation different pharmacologic and non pharmacological
Behzad Maghsoodi, Seyed Ahmad Rakeie, Seyed Ziaoldin Behin Aeen   +2 more
doaj  

The effect of oral clonidine premedication on blood loss in primary total hip arthroplasty: A randomized placebo-controlled trial [PDF]

Archives of Trauma Research
Background: Substantial blood loss is a major concern in primary total hip arthroplasty and thus various blood conservation techniques are used to reduce blood loss in this surgery.
Shideh Dabir, Reza Zandi, Mastaneh Dahi Taleghani, Mohammadreza Moshari, Rahil Farahani, Maryam Vosoughian, Soudeh Tabashi   +6 more
doaj   +1 more source

Prenatal exposure to antihypertensive medication: A systematic review of neurodevelopmental and educational outcomes

JCPP Advances, EarlyView.
This systematic review investigated the association of prenatal exposure to antihypertensive medication with longer‐term poor neurodevelopmental outcomes by evaluating the findings from existing literature. We undertook a systematic review of previous studies looking specifically at neurodevelopmental outcomes in children.
Shrifah Alkhalaf, Sarjit Singh, Jill P. Pell, Scott M. Nelson, Daniel F. Mackay, Michael Fleming   +5 more
wiley   +1 more source

Effect of Oral Clonidine Premedication on Induction Dose of Propofol and Perioperative Haemodynamic Parameters in Patients Undergoing Laparoscopic Cholecystectomy: A Double-blinded Randomised Controlled Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Clonidine increases the effects of anaesthesia and possesses antihypertensive qualities. During laparoscopic cholecystectomy, pneumoperitoneum is created by inflating Carbon Dioxide (CO2), which stimulates autonomic pathways, resulting in ...
Dheer Singh, Rakesh Bahadur Singh, Matendra Singh Yadav, Amit Kumar Singh, Purva Kumrawat, Chandra Bhushan Yadav   +5 more
doaj   +1 more source