Results 11 to 20 of about 31,656 (234)

The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses [PDF]

BMC Pharmacology and Toxicology, 2018
Background The Oslo Study of Clonidine in Elderly Patients with Delirium (LUCID) is an RCT investigating the effect of clonidine in medical patients > 65 years with delirium.
Karen Roksund Hov, Bjørn Erik Neerland, Anders Mikal Andersen, Øystein Undseth, Vegard Bruun Wyller, Alasdair M. J. MacLullich, Eva Skovlund, Eirik Qvigstad, Torgeir Bruun Wyller   +8 more
doaj   +2 more sources

Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal

Case Reports in Pediatrics, 2022
Background. Clonidine, a central alpha-adrenoreceptor agonist, was initially developed as an antihypertensive. Though no longer commonly used for its original indication due to rebound hypertension after discontinuation, it is currently widely prescribed
Can Cao, Matthew L. Lorenz, Phillip Sojka, Allison W. Brindle, Lisa Swartz Topor   +4 more
doaj   +2 more sources

Clonidine protects rat hippocampal and cortical neurons from oxygen-glucose deprivation and reoxygenation-induced injury through HCN Channels [PDF]

Scientific Reports
Our prior research demonstrated that the neuroprotective effects of clonidine can be reversed by yohimbine, an α2-adrenergic receptor antagonist. Additionally, clonidine has been shown to alleviate anxiety-like behavior in rats after bilateral common ...
Ke Wang, Wen-Jing Yan, Gang Li, Jue Liu, Yue Chen, Zi-Cheng Li, Zhi He   +6 more
doaj   +2 more sources

The effect of clonidine as preanesthetic medication in children

Iranian South Medical Journal, 2003
Separation of children from their parents at the time of transfer to operating room commonly cause severe anxiety which can induce undesired physiologic and psychologic Sequalea. For the purpose of sedation different pharmacologic and non pharmacological
Behzad Maghsoodi, Seyed Ahmad Rakeie, Seyed Ziaoldin Behin Aeen   +2 more
doaj   +1 more source

Clonidine versus other adjuncts added to local anesthetics for pediatric neuraxial blocks: a systematic review and meta-analysis

Journal of Pain Research, 2018
Yang Yang,1,2 Ling-Yu Yu,3 Wen-Sheng Zhang1,2 1Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Anesthesiology, West
Yang Y, Yu LY, Zhang WS
doaj   +1 more source

Electrophysiological evidence about sexual dimorphism in the clonidine-induced inhibition of trigeminal wide dynamic range cell activity [PDF]

The Journal of Headache and Pain
Background The trigeminal system plays a key role in headaches pathophysiology. In this regard, nociceptive experiments in male rodents have shown that at the trigeminal level, clonidine induces antinociception through α2A- but not α2B/2C-adrenoceptors ...
Gustavo López-Córdoba, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Abimael González-Hernández   +3 more
doaj   +2 more sources

The Use of Intravenous Clonidine in Postoperative Pain Management: A Scoping Review. [PDF]

Acta Anaesthesiol Scand
ABSTRACT Background Clonidine, an alpha‐2 receptor agonist, has been explored as a potential analgesic in postoperative pain management, but its efficacy and safety profile remain unclear. The aim of this scoping review was to present the evidence on the use of intravenous clonidine in postoperative pain management.
Mohr T, Tsuchiya EA, Krag M, Dybdal B, Heiberg J.   +4 more
europepmc   +2 more sources

Evaluating the Impact of Clonidine and Midazolam Premedication on Emergence Delirium in Pediatric Patients. [PDF]

Paediatr Anaesth
ABSTRACT Background Preoperative anxiety is common in children and is associated with emergence delirium—a distressing postoperative complication characterized by agitation and disorientation. Midazolam has long been the drug of choice for preoperative anxiolysis.
Garioud ALB, Taplin A, Shang Y, Khan RN, Sommerfield D, Hauser N, Sommerfield A, von Ungern-Sternberg BS.   +7 more
europepmc   +2 more sources

The Addition of Intrathecal Clonidine to Reduce Medication-Related Side-Effects in Cancer Pain: A Retrospective Cohort Study [PDF]

Journal of Pain Research
Evgeny Bulat,1 Rahul Chaturvedi,2 Peyton Johnson,2 Neal Rakesh,3 Amitabh Gulati3 1Pain Treatment Specialists, VIP Medical Group, New York, NY, USA; 2Department of Anesthesiology, NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, USA ...
Bulat E, Chaturvedi R, Johnson P, Rakesh N, Gulati A   +4 more
doaj   +1 more source

Effects of α2-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum.

PLoS ONE, 2022
The sympathetic nervous system is highly involved in the regulation of gastrointestinal functions such as luminal alkalinisation and fluid absorption. However, the exact mechanisms are not clear.
Olof Nylander, Markus Sjöblom, John Sedin, David Dahlgren   +3 more
doaj   +1 more source