The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses [PDF]
BMC Pharmacology and Toxicology, 2018 Background The Oslo Study of Clonidine in Elderly Patients with Delirium (LUCID) is an RCT investigating the effect of clonidine in medical patients > 65 years with delirium.
Karen Roksund Hov +8 more
doaj +4 more sources
A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning [PDF]
Trials, 2009 Background An estimated 2–3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies.
Karunatilake Harindra +6 more
doaj +3 more sources
ADHD medications and drug withdrawal: A pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database. [PDF]
PCN RepPsychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Ebina T, Iwamoto K, Ikeda M.
europepmc +2 more sources
Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in oocytes [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundClonidine has been shown to be a potent neuroprotectant by acting at α2 receptors on glutamatergic neurons to inhibit the release of glutamate.
Jae Hee Woo +3 more
doaj +1 more source
Symptomatic treatment of children with anti-NMDAR encephalitis. [PDF]
, 2016 AIM: We performed the first study on the perceived benefit and adverse effects of symptomatic management in children with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis.
Brilot, F +7 more
core +1 more source
Topical treatment of peripheral neuropathic pain: applying the evidence [PDF]
, 2017 Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief with currently recommended first-line oral treatments, which are also associated with systemic adverse events.
Cruccu, Giorgio, Sommer, Claudia
core +1 more source
Alcohol Withdrawal – Therapeutical Management in Surgical Patients with Upper Intestinal Bleeding [PDF]
, 2015 Psychological dependence involves a desire to use a drug to avoid the unpleasant withdrawal syndrome that results from cessation of exposure to it. Alcohol withdrawal syndrome is one of the most feared complications of alcohol addiction and sometimes can
Bogdan, Popescu +5 more
core +4 more sources
Pharmacological treatment strategies to manage precipitated withdrawal following the administration of buprenorphine in opioid use disorder: A systematic review. [PDF]
AddictionAbstract Background and aims There has been limited evidence synthesis examining the treatment of buprenorphine precipitated opioid withdrawal (BPOW). We aimed to conduct the first systematic review to assess the clinical utility of any pharmacological intervention in the management of BPOW.
Roberts E, Kalk N, Strang J.
europepmc +2 more sources
Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) [PDF]
, 2018 The main remit of the European Society for Paediatric Anaesthesiology (ESPA) Pain Committee is to improve the quality of pain management in children. The ESPA Pain Management Ladder is a clinical practice advisory based upon expert consensus to help to ...
Adamek +196 more
core +1 more source
SAGE Open Medicine, 2015 Objectives: Limited literature exists examining the use of enteral clonidine to transition patients from dexmedetomidine for management of agitation. The aim of this study was to evaluate dexmedetomidine discontinuation within 8 h of enteral clonidine ...
Kimberly Terry +2 more
doaj +1 more source